| GeneLibs

题目:: Establishment of a new glial cell line from hippocampus of prion protein gene-deficient mice.
作者:: Nishimura(Takuya),Sakudo(Akikazu),Xue(Guangai),Ikuta(Kazuyoshi),Yukawa(Masayoshi),Sugiura(Katsuaki),Onodera(Takashi)
状态:: 发布时间2008-11-28 , 更新时间 2016-11-24
期刊:: Biochem Biophys Res Commun
摘要:: Cellular prion protein (PrP(C)) is expressed not only in neuronal cells but also in non-neuronal cells such as astroglial cells. In the present study, the prion protein (PrP) gene (Prnp)-deficient astroglial cell line GpL1 from hippocampal cells of ZrchI Prnp(-/-) mice were established. Transfection of Prnp suppressed cell death in GpL1 cells under serum-free conditions. The PrP-expressing GpL1 cells showed increased superoxide dismutase activity compared to control GpL1 cells. These results suggest that the anti-oxidative activity of PrP(C) functions in not only neuronal cells but also astroglial cells possibly due to the increased anti-oxidative activity of astroglial cells.
语言:: eng
DOI:: 10.1016/j.bbrc.2008.10.087

文献库文献相关信息