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PMID: 18927607 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3.

PloS one ·Vol. 3 ·No. 10 ·2008-00-00 ·Pages e3421

Okubadejo N, Britton A, Crews C, Akinyemi R, Hardy J, Singleton A, Bras J

Abstract

Several genetic variations have been associated with Parkinson disease in different populations over the past few years. Although a considerable number of worldwide populations have been screened for these variants, results from Sub-Saharan populations are very scarce in the literature. In the present report we have screened a cohort of Parkinson disease patients (n = 57) and healthy controls (n = 51) from Nigeria for mutations in the genes PRKN, LRRK2 and ATXN3. No pathogenic mutations were found in any of the genes. Hence, common pathogenic mutations in these genes, observed in several different populations, are not a frequent cause of Parkinson disease in Nigeria.

MeSH Terms
Adult Aged Ataxin-3 Case-Control Studies Cohort Studies DNA Mutational Analysis Female Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Middle Aged Mutation Nerve Tissue Proteins/genetics Nigeria Nuclear Proteins/genetics Parkinson Disease/epidemiology,genetics Protein Serine-Threonine Kinases/genetics Repressor Proteins/genetics Ubiquitin-Protein Ligases/genetics
Chemicals
Nerve Tissue Proteins Nuclear Proteins Repressor Proteins Ubiquitin-Protein Ligases parkin protein LRRK2 protein, human Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Protein Serine-Threonine Kinases ATXN3 protein, human Ataxin-3
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Okubadejo Njideka
Neurology Unit, Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria.
Britton Angela
Crews Cynthia
Akinyemi Rufus
Hardy John
Singleton Andrew
Bras Jose
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Article Info
Journal
PloS one
Abbr.
PLoS One
ISSN
1932-6203
DOI
10.1371/journal.pone.0003421
Published
2008-00-00
Epub
2008-00-17
Pages
e3421
Language
English
Region
United States
NLM ID
101285081
PMCID
PMC2559870
Subset
IM
Grants
Parkinson's UK · G-0907 · United Kingdom
Medical Research Council · G0701075 · United Kingdom
Intramural NIH HHS · Z01 AG000957 · United States
NIA NIH HHS · Z01-AG000957-05 · United States
External Links
PubMed source DOI: 10.1371/journal.pone.0003421 PMC Full Text View journal details
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