Phosphoproteomics: unraveling the signaling web.
In recent years, phosphoproteomic technologies have increased our understanding of cellular signaling networks. Here, we frame recent phosphoproteomics-based advances in the context of the DNA damage response and ErbB receptor family signaling and offer a perspective on how the molecular insights arising from the integration of such proteomic approaches might be used for clinical applications.
16 references, click to expand
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease.J Clin Oncol. 1999 Sep;17(9):2639-48 PMID: 10561337
-
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma.Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12867-72 PMID: 17646646
-
ERBB receptors and cancer: the complexity of targeted inhibitors.Nat Rev Cancer. 2005 May;5(5):341-54 PMID: 15864276
-
Control of MAPK signalling: from complexity to what really matters.Oncogene. 2005 Aug 25;24(36):5533-42 PMID: 16007170
-
Actin microfilament aggregation induced by withaferin A is mediated by annexin II.Nat Chem Biol. 2006 Jan;2(1):33-8 PMID: 16408090
-
A biological approach to computational models of proteomic networks.Curr Opin Chem Biol. 2006 Feb;10(1):73-80 PMID: 16406679
-
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration.Mol Syst Biol. 2006;2:54 PMID: 17016520
-
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies.Science. 2007 Oct 12;318(5848):287-90 PMID: 17872411
-
Profiling of UV-induced ATM/ATR signaling pathways.Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19855-60 PMID: 18077418
-
ATR regulates hexavalent chromium-induced S-phase checkpoint through phosphorylation of SMC1.Mutat Res. 2006 Nov 7;610(1-2):14-20 PMID: 16876463
-
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.Cell. 2006 Nov 3;127(3):635-48 PMID: 17081983
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling.Science. 2007 May 18;316(5827):1039-43 PMID: 17463250
-
Modeling HER2 effects on cell behavior from mass spectrometry phosphotyrosine data.PLoS Comput Biol. 2007 Jan 5;3(1):e4 PMID: 17206861
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.Science. 2007 May 25;316(5828):1160-6 PMID: 17525332
-
High-throughput phosphotyrosine profiling using SH2 domains.Mol Cell. 2007 Jun 22;26(6):899-915 PMID: 17588523
-
Parameter sensitivity as a criterion for evaluating and comparing the performance of biochemical systems.Nature. 1971 Feb 19;229(5286):542-4 PMID: 4925348
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