Deleterious CNS effects of the APOE epsilon4 allele in individuals with HIV-1 infection may be age-dependent.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 105 ·No. 41 ·2008-10-14 ·Pages E65; author reply E67-8

Pomara N, Belzer K, Sidtis JJ

Abstract

暂无摘要

MeSH Terms

AIDS Dementia Complex/etiology Age Factors Alleles Apolipoprotein E4/genetics Central Nervous System/physiopathology HIV Infections/physiopathology Humans

Chemicals

Apolipoprotein E4

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Pomara Nunzio

Belzer Kenneth

Sidtis John J

References (5)

5 references, click to expand

HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy.
Nat Med. 1998 Oct;4(10):1182-4 PMID: 9771753
HIV dementia and apolipoprotein E.
Acta Neurol Scand. 1997 May;95(5):315-8 PMID: 9188909
The apolipoprotein E epsilon4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challenge.
Psychopharmacology (Berl). 2008 Nov;201(1):125-35 PMID: 18668226
Age, apolipoprotein E4, and the risk of HIV dementia: the Hawaii Aging with HIV Cohort.
J Neuroimmunol. 2004 Dec;157(1-2):197-202 PMID: 15579298
Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression.
Proc Natl Acad Sci U S A. 2008 Jun 24;105(25):8718-23 PMID: 18562290

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

1091-6490

DOI

10.1073/pnas.0806356105

Published

2008-10-14

Epub

2008-00-08

Pages

E65; author reply E67-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC2572941

Subset

Corrections

CommentOn

PMID: 18562290

External Links

PubMed source DOI: 10.1073/pnas.0806356105 PMC Full Text View journal details

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Deleterious CNS effects of the APOE epsilon4 allele in individuals with HIV-1 infection may be age-dependent.

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