Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

Cancer cell ·Vol. 14 ·No. 4 ·2008-10-07 ·Pages 281-3

Ruiz i Altaba A

Abstract

Hedgehog (HH)-GLI signaling is a developmental patterning pathway used by many tumors for bulk proliferation that has been shown also to regulate cancer stem cell self-renewal and survival. Surprisingly, a recent study by Yauch et al. (2008) proposes that HH-GLI signaling acts only on the tumor stroma. The mode of action of HH-GLI signaling in cancer may shape the development of therapeutic antagonists.

MeSH Terms

Animals Antineoplastic Agents/pharmacology Cell Proliferation/drug effects Cell Survival/drug effects Epithelial Cells/drug effects,metabolism Hedgehog Proteins/metabolism Humans Neoplasms/drug therapy,metabolism,pathology Neoplastic Stem Cells/drug effects,metabolism Paracrine Communication/drug effects Receptors, G-Protein-Coupled/antagonists & inhibitors,metabolism Signal Transduction/drug effects Smoothened Receptor Stromal Cells/drug effects,metabolism Transcription Factors/metabolism Zinc Finger Protein GLI1

Chemicals

Antineoplastic Agents GLI1 protein, human Hedgehog Proteins Receptors, G-Protein-Coupled SMO protein, human Smoothened Receptor Transcription Factors Zinc Finger Protein GLI1

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ruiz i Altaba Ariel

Department of Genetic Medicine and Development, University of Geneva Medical School, CH-1211 Geneva, Switzerland. ariel.ruizaltaba@unige.ch

Article Info

Journal

Cancer cell

Abbr.

Cancer Cell

ISSN

1878-3686

DOI

10.1016/j.ccr.2008.09.007

ariel.ruizaltaba@unige.ch

Published

2008-10-07

Pages

281-3

Language

English

Region

United States

NLM ID

101130617

Subset

External Links

PubMed source DOI: 10.1016/j.ccr.2008.09.007 View journal details

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Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

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