The jury is in: p73 is a tumor suppressor after all.

Genes & development ·Vol. 22 ·No. 19 ·2008-10-01 ·Pages 2591-5

Rosenbluth JM, Pietenpol JA

Abstract

While p53 has been extensively characterized as a tumor suppressor, it has been more difficult to determine whether p63 and/or p73 play a similar role. Every system in which these family members have been studied, from cells to animal models to human tissues, seems to create more questions than answers. Tomasini and colleagues (2677-2691) demonstrate that one isoform of p73 is responsible for preventing tumor formation in vivo, providing critical validation of an isoform-based model of p73 function.

MeSH Terms

Animals DNA-Binding Proteins/deficiency,genetics,physiology Female Genes, Tumor Suppressor Genomic Instability Humans Infertility/genetics Male Mice Mice, Knockout Models, Biological Mutation Neoplasms/etiology,genetics,prevention & control Nuclear Proteins/deficiency,genetics,physiology Protein Isoforms/genetics,physiology Signal Transduction Tumor Protein p73 Tumor Suppressor Proteins/deficiency,genetics,physiology

Chemicals

DNA-Binding Proteins Nuclear Proteins Protein Isoforms TP73 protein, human Trp73 protein, mouse Tumor Protein p73 Tumor Suppressor Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rosenbluth Jennifer M

Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennesee 37232, USA.

Pietenpol Jennifer A

Article Info

Journal

Genes & development

Abbr.

Genes Dev

ISSN

0890-9369

DOI

10.1101/gad.1727408

Published

2008-10-01

Pages

2591-5

Language

English

Region

United States

NLM ID

8711660

Subset

Corrections

CommentOn

PMID: 18805989

External Links

PubMed source DOI: 10.1101/gad.1727408 View journal details

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The jury is in: p73 is a tumor suppressor after all.

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