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题目:: Tamoxifen induces regression of estradiol-induced mammary cancer in the ACI.COP-Ept2 rat model.
作者:: Ruhlen(Rachel L),Willbrand(Dana M),Besch-Williford(Cynthia L),Ma(Lixin),Shull(James D),Sauter(Edward R)
状态:: 发布时间2009-09-17 , 更新时间 2016-10-25
期刊:: Breast Cancer Res Treat
摘要:: The ACI rat is a unique model of human breast cancer in that mammary cancers are induced by estrogen without carcinogens, irradiation, xenografts or transgenic manipulations. We sought to characterize mammary cancers in a congenic variant of the ACI rat, the ACI.COP-Ept2. All rats with estradiol implants developed mammary cancers in 5-7 months. Rats bearing estradiol-induced mammary cancers were treated with tamoxifen for three weeks. Tamoxifen reduced tumor mass, measured by magnetic resonance imaging, by 89%. Tumors expressed estrogen receptors (ER), progesterone receptor (PR), and Erbb2. ERalpha and PR were overexpressed in tumor compared to adjacent non-tumor mammary gland. Thus, this model is highly relevant to hormone responsive human breast cancers.
语言:: eng
DOI:

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