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PMID: 188133 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Slow persistent infection caused by visna virus: role of host restriction.

Science (New York, N.Y.) ·Vol. 195 ·No. 4274 ·1977-01-14 ·Pages 175-7

Haase AT, Stowring L, Narayan P, Griffin D, Price D

Abstract

Proviral DNA has been demonstrated by in situ hybridization in foci of cells of a lamb infected with the RNA slow virus visna. A few of these cells also contain the major virion structural antigen p30. This restriction in virus gene expression in the infected animal provides a mechanism for persistence of virus in this chronic infection.

MeSH Terms

Animals Cell Nucleus/microbiology Choroid Plexus/microbiology Culture Techniques DNA, Viral/analysis RNA Viruses/growth & development Sheep Viral Proteins/analysis Virus Replication Visna-maedi virus/analysis,growth & development

Chemicals

DNA, Viral Viral Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Haase A T

Stowring L

Narayan P

Griffin D

Price D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.188133

Published

1977-01-14

Pages

175-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.188133 View journal details

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