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LiteratureArticle Details
PMID: 18806794
Published · ppublish
English
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism.
Abstract
Here we present a draft genome sequence of the nematode Pristionchus pacificus, a species that is associated with beetles and is used as a model system in evolutionary biology. With 169 Mb and 23,500 predicted protein-coding genes, the P. pacificus genome is larger than those of Caenorhabditis elegans and the human parasite Brugia malayi. Compared to C. elegans, the P. pacificus genome has more genes encoding cytochrome P450 enzymes, glucosyltransferases, sulfotransferases and ABC transporters, many of which were experimentally validated. The P. pacificus genome contains genes encoding cellulase and diapausin, and cellulase activity is found in P. pacificus secretions, indicating that cellulases can be found in nematodes beyond plant parasites. The relatively higher number of detoxification and degradation enzymes in P. pacificus is consistent with its necromenic lifestyle and might represent a preadaptation for parasitism. Thus, comparative genomics analysis of three ecologically distinct nematodes offers a unique opportunity to investigate the association between genome structure and lifestyle.
MeSH Terms
Amino Acid Sequence
Animals
Caenorhabditis elegans/genetics
Chromosome Mapping
Coleoptera/parasitology
Evolution, Molecular
Exons/genetics
Genes, Helminth
Genome, Helminth
Host-Parasite Interactions
Intestines/parasitology
Introns/genetics
Molecular Sequence Data
Nematoda/physiology
Phylogeny
Sequence Homology, Amino Acid
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
Published
2008-10-00
Epub
2008-00-21
Pages
1193-8
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC3816844
Subset
IM
Grants
NHGRI NIH HHS · U54 HG003079 · United States
Databases
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