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LiteratureArticle Details
PMID: 18799311
Published · ppublish
English
Journal Article
Research Support, Non-U.S. Gov't
Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP.
Abstract
The synthesis of mono- and bisphosphorothioate analogues of 3',5'-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.
MeSH Terms
Bronchi/metabolism
Chemistry, Pharmaceutical/methods
Chromatography, High Pressure Liquid
Cyclic GMP/analogs & derivatives,chemical synthesis,chemistry
Dose-Response Relationship, Drug
Drug Design
Humans
Immune System
Inflammation
Models, Chemical
Neutrophils/metabolism
Organophosphonates/chemistry
Phosphates/chemistry
Vaccines/chemistry
Chemicals
Organophosphonates
Phosphates
Vaccines
bis(3',5')-cyclic diguanylic acid
Cyclic GMP
thiophosphoric acid
Article Info
Journal
Bioorganic & medicinal chemistry letters
Abbr.
Bioorg Med Chem Lett
ISSN
1464-3405
Email
Published
2008-10-15
Epub
2008-00-29
Pages
5631-4
Language
English
Region
England
NLM ID
9107377
Subset
IM
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