Home LiteratureArticle Details
PMID: 18781329 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

LRRK2 R1628P increases risk of Parkinson's disease: replication evidence.

Human genetics ·Vol. 124 ·No. 3 ·2008-10-00 ·Pages 287-8

Tan EK, Tan LC, Lim HQ, Li R, Tang M, Yih Y, Pavanni R, Prakash KM, Fook-Chong S, Zhao Y

Abstract

We showed that the frequency of a LRRK2 variant (c.4883G > C, R1628P) was higher in Parkinson's disease (PD) compared to controls (8.4 vs. 3.4%, P = 0.046, OR 2.5, 95% CI 1.1-5.6). In the multivariate logistic regression (with adjustments made for the effect of age, age of onset, and gender), the heterozygous R1628P genotype was associated with an increased risk of PD compared to controls (OR 3.3, 95% CI 1.4- 7.9, P = 0.007). We provided an independent confirmation that the R1628P variant increases the risk of PD among Chinese.

MeSH Terms
Adult Aged Aged, 80 and over Case-Control Studies China Female Genetic Predisposition to Disease Genetic Variation Genotype Heterozygote Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Middle Aged Parkinson Disease/ethnology,genetics Protein Serine-Threonine Kinases/genetics,physiology Risk
Chemicals
LRRK2 protein, human Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Protein Serine-Threonine Kinases
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Tan E K
Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Outram Road, Singapore, 169608, Singapore. gnrtek@sgh.com.sg
Tan Louis C
Lim H Q
Li R
Tang M
Yih Yuen
Pavanni R
Prakash K M
Fook-Chong S
Zhao Yi
References (7)
7 references, click to expand
  1. The LRRK2 Gly2385Arg variant is associated with Parkinson's disease: genetic and functional evidence.
    Hum Genet. 2007 Feb;120(6):857-63 PMID: 17019612
  2. Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.
    J Neurosci Res. 2008 Jul;86(9):1895-901 PMID: 18338801
  3. Uniting Chinese across Asia: the LRRK2 Gly2385Arg risk variant.
    Eur J Neurol. 2008 Mar;15(3):203-4 PMID: 18290841
  4. Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia.
    Parkinsonism Relat Disord. 2007 Mar;13(2):89-92 PMID: 17222580
  5. Analysis of 14 LRRK2 mutations in Parkinson's plus syndromes and late-onset Parkinson's disease.
    Mov Disord. 2006 Jul;21(7):997-1001 PMID: 16602113
  6. A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan.
    Neurogenetics. 2006 Jul;7(3):133-8 PMID: 16633828
  7. Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease.
    Ann Neurol. 2008 Jul;64(1):88-92 PMID: 18412265
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
1432-1203
DOI
10.1007/s00439-008-0544-2
Email
gnrtek@sgh.com.sg
Published
2008-10-00
Epub
2008-00-10
Pages
287-8
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/s00439-008-0544-2 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2