Is hsp70 the cellular thermometer?

Trends in biochemical sciences ·Vol. 16 ·No. 4 ·1991-04-00 ·Pages 135-40

Craig EA, Gross CA

Abstract

Cells respond to an increase in temperature by inducing the synthesis of the heat shock proteins, which are a small set of evolutionarily conserved proteins. We review the evidence leading us to suggest that the free pool of one of these proteins, hsp70, serves as a cellular thermometer that regulates the expression of all heat shock proteins.

MeSH Terms

Animals Eukaryotic Cells/physiology Heat-Shock Proteins/physiology Prokaryotic Cells/physiology Temperature

Chemicals

Heat-Shock Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Craig E A

Department of Physiological Chemistry, University of Wisconsin-Madison 53706.

Gross C A

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/0968-0004(91)90055-z

Published

1991-04-00

Pages

135-40

Language

English

Region

England

NLM ID

7610674

Subset

External Links

PubMed source DOI: 10.1016/0968-0004(91)90055-z View journal details

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Is hsp70 the cellular thermometer?

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