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PMID: 18725296 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Signaling by death receptors in the nervous system.

Current opinion in neurobiology ·Vol. 18 ·No. 3 ·2008-06-00 ·Pages 284-91

Haase G, Pettmann B, Raoul C, Henderson CE

Abstract

Cell death plays an important role both in shaping the developing nervous system and in neurological disease and traumatic injury. In spite of their name, death receptors can trigger either cell death or survival and growth. Recent studies implicate five death receptors--Fas/CD95, TNFR1 (tumor necrosis factor receptor-1), p75NTR (p75 neurotrophin receptor), DR4, and DR5 (death receptors-4 and -5)--in different aspects of neural development or degeneration. Their roles may be neuroprotective in models of Parkinson's disease, or pro-apoptotic in ALS and stroke. Such different outcomes probably reflect the diversity of transcriptional and posttranslational signaling pathways downstream of death receptors in neurons and glia.

MeSH Terms
Animals Nervous System Physiological Phenomena Receptors, Death Domain/metabolism Signal Transduction/physiology
Chemicals
Receptors, Death Domain
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Haase Georg
Developmental Biology Institute of Marseille-Luminy, IBDML, CNRS UMR 6216, Marseille Cedex 09, France.
Pettmann Brigitte
Raoul Cédric
Henderson Christopher E
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Article Info
Journal
Current opinion in neurobiology
Abbr.
Curr Opin Neurobiol
ISSN
0959-4388
DOI
10.1016/j.conb.2008.07.013
Published
2008-06-00
Pages
284-91
Language
English
Region
England
NLM ID
9111376
PMCID
PMC2668142
Subset
IM
Grants
NINDS NIH HHS · R01 NS056422 · United States
NINDS NIH HHS · R01 NS056422-01A1 · United States
NINDS NIH HHS · R01 NS056422-02 · United States
External Links
PubMed source DOI: 10.1016/j.conb.2008.07.013 PMC Full Text View journal details
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