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PMID: 187151 Published · ppublish English Journal Article

Inhibitors of foot-and-mouth disease virus. Temperature-dependence of the effect of guanidine on virus growth.

Archives of virology ·Vol. 52 ·No. 1-2 ·1976-00-00 ·Pages 71-83

Nick H, Ahl R

Abstract

In suspended secondary calf kidney cells infected with foot-and-mouth disease virus (FMDV) the temperature range for optimal virus growth is shifted down by 3 to 5 degrees C in the presence of 1--2 mM guanidine. For some virus strains this shift is so effective that at infraoptimal temperatures virus yield in guanidine-treated cells exceeds that of the corresponding control by more than one log10. On the contrary, at supraoptimal temperatures inhibition of virus growth by the drug is strongly enhanced. At a concentration of 1 to 2 mM guanidine virus yield reduction or enhancement is based on a decrease in increase, respectively, of the number of virus producing cells (infective centers; I.C.), while virus yield per I.C. is less affected. Besides this "thermomimetic" effect virus production is inhibited by guanidine depending on the concentration of this substance. A mutant of FMDV strain O1L, resistant to 4.2 guanidine, did not differ from the original virus in its antigenic behaviour in the passive immunohemolysis test.

MeSH Terms
Aphthovirus/growth & development,immunology Cell Line Guanidines/pharmacology Hemolysis Temperature Virus Replication/drug effects
Chemicals
Guanidines
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nick H
Ahl R
References (37)
37 references, click to expand
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Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
DOI
10.1007/BF01317866
Published
1976-00-00
Pages
71-83
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01317866 View journal details
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