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PMID: 18711365 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

Nature genetics ·Vol. 40 ·No. 9 ·2008-09-00 ·Pages 1056-8

Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N, Wellcome Trust Case Control Consortium

Abstract

To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 x 10(-9)) in ANK3 (ankyrin G). We also found further support for the previously reported CACNA1C (alpha 1C subunit of the L-type voltage-gated calcium channel; combined P = 7.0 x 10(-8), rs1006737). Our results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder.

MeSH Terms
Ankyrins/genetics Bipolar Disorder/genetics Calcium Channels, L-Type/genetics Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 15 Genetic Predisposition to Disease Genome-Wide Association Study Humans Logistic Models Polymorphism, Single Nucleotide
Chemicals
ANK3 protein, human Ankyrins CACNA1C protein, human Calcium Channels, L-Type
Authors & Affiliations
63 authors, click to expand affiliations / ORCID
Ferreira Manuel A R
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
O'Donovan Michael C
Meng Yan A
Jones Ian R
Ruderfer Douglas M
Jones Lisa
Fan Jinbo
Kirov George
Perlis Roy H
Green Elaine K
Smoller Jordan W
Grozeva Detelina
Stone Jennifer
Nikolov Ivan
Chambert Kimberly
Hamshere Marian L
Nimgaonkar Vishwajit L
Moskvina Valentina
Thase Michael E
Caesar Sian
Sachs Gary S
Franklin Jennifer
Gordon-Smith Katherine
Ardlie Kristin G
Gabriel Stacey B
Fraser Christine
Blumenstiel Brendan
Defelice Matthew
Breen Gerome
Gill Michael
Morris Derek W
Elkin Amanda
Muir Walter J
McGhee Kevin A
Williamson Richard
MacIntyre Donald J
MacLean Alan W
St Clair David
Robinson Michelle
Van Beck Margaret
Pereira Ana C P
Kandaswamy Radhika
McQuillin Andrew
Collier David A
Bass Nicholas J
Young Allan H
Lawrence Jacob
Ferrier I Nicol
Anjorin Adebayo
Farmer Anne
Curtis David
Scolnick Edward M
McGuffin Peter
Daly Mark J
Corvin Aiden P
Holmans Peter A
Blackwood Douglas H
Gurling Hugh M
Owen Michael J
Purcell Shaun M
Sklar Pamela
Craddock Nick
Wellcome Trust Case Control Consortium
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Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1061-4036
DOI
10.1038/ng.209
Published
2008-09-00
Pages
1056-8
Language
English
Region
United States
NLM ID
9216904
PMCID
PMC2703780
Subset
IM
Grants
Medical Research Council · G0701003 · United Kingdom
Medical Research Council · G9309834 · United Kingdom
NIMH NIH HHS · R01 MH062137 · United States
Wellcome Trust · 082371 · United Kingdom
Wellcome Trust · 077011 · United Kingdom
Medical Research Council · G9623693N · United Kingdom
Medical Research Council · G0500791 · United Kingdom
NIMH NIH HHS · MH63420 · United States
NIMH NIH HHS · R01 MH067288 · United States
NIMH NIH HHS · R01 MH063420 · United States
NIMH NIH HHS · MH067288 · United States
NIMH NIH HHS · R01 MH063445 · United States
NIMH NIH HHS · MH062137 · United States
Wellcome Trust · 076113 · United Kingdom
Chief Scientist Office · United Kingdom
NIMH NIH HHS · N01MH80001 · United States
NCRR NIH HHS · U54 RR020278 · United States
NIMH NIH HHS · MH063445 · United States
Corrections
CommentIn
PMID: 19165917
External Links
PubMed source DOI: 10.1038/ng.209 PMC Full Text View journal details
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