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题目:: Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis.
作者:: Heikkilä(Katriina),Harris(Ross),Lowe(Gordon),Rumley(Ann),Yarnell(John),Gallacher(John),Ben-Shlomo(Yoav),Ebrahim(Shah),Lawlor(Debbie A)
状态:: 发布时间2009-01-15 , 更新时间 2016-11-22
期刊:: Cancer Causes Control
摘要:: We investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk.,We examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women's Heart and Health Study (4,286 women aged 60-80) and the Caerphilly Cohort (2,398 men aged 45-59) using Cox regression and pooled our findings with previous prospective studies' in fixed and random effects meta-analyses.,CRP and IL-6 were associated with some incident cancers in our cohorts, but the numbers of cancer cases were small. In our meta-analyses elevated CRP was associated with an increased overall risk of cancer (random effects estimate (RE): 1.10, 95% CI: 1.02, 1.18) and lung cancer (RE: 1.32, 95% CI: 1.08, 1.61). Its associations with colorectal (RE: 1.09, 95% CI: 0.98, 1.21) and breast cancer risks (RE: 1.10, 95% CI: 0.97, 1.26) were weaker. CRP appeared unrelated to prostate cancer risk (RE: 1.00 0.88, 1.13). IL-6 was associated with increased lung and breast cancer risks and decreased prostate cancer risk, and was unrelated to colorectal cancer risk.,Our findings suggest an etiological role for CRP and IL-6 in some cancers. Further large prospective and genetic studies would help to better understand this role.
语言:: eng
DOI:: 10.1007/s10552-008-9212-z

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