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PMID: 18703742 Published · ppublish English Journal Article Research Support, N.I.H., Intramural

In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies.

Science (New York, N.Y.) ·Vol. 321 ·No. 5891 ·2008-08-15 ·Pages 970-4

Peters NC, Egen JG, Secundino N, Debrabant A, Kimblin N, Kamhawi S, Lawyer P, Fay MP, Germain RN, Sacks D

Abstract

Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by direct parasitization of macrophages, but the early events following transmission to the skin by vector sand flies have been difficult to examine directly. Using dynamic intravital microscopy and flow cytometry, we observed a rapid and sustained neutrophilic infiltrate at localized sand fly bite sites. Invading neutrophils efficiently captured Leishmania major (L.m.) parasites early after sand fly transmission or needle inoculation, but phagocytosed L.m. remained viable and infected neutrophils efficiently initiated infection. Furthermore, neutrophil depletion reduced, rather than enhanced, the ability of parasites to establish productive infections. Thus, L.m. appears to have evolved to both evade and exploit the innate host response to sand fly bite in order to establish and promote disease.

MeSH Terms
Animals Apoptosis Cell Movement Flow Cytometry Host-Parasite Interactions Insect Bites and Stings Insect Vectors/parasitology Leishmania major/immunology,physiology Leishmaniasis, Cutaneous/immunology,parasitology,transmission Macrophages/parasitology Mice Mice, Inbred C57BL Mice, Transgenic Microscopy Neutrophil Infiltration Neutrophils/immunology,parasitology,physiology Phagocytosis Phlebotomus/parasitology Skin/immunology,parasitology
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Peters Nathan C
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.
Egen Jackson G
Secundino Nagila
Debrabant Alain
Kimblin Nicola
Kamhawi Shaden
Lawyer Phillip
Fay Michael P
Germain Ronald N
Sacks David
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Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
Published
2008-08-15
Pages
970-4
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2606057
Subset
IM
Grants
Intramural NIH HHS · Z01 AI000256-26 · United States
Intramural NIH HHS · Z01 AI000494-21 · United States
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