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题目:: Cytonemes and tunneling nanotubules in cell-cell communication and viral pathogenesis.
作者:: Sherer(Nathan M),Mothes(Walther)
状态:: 发布时间2008-08-29 , 更新时间 2016-11-22
期刊:: Trends Cell Biol
摘要:: Cells use a variety of intercellular structures, including gap junctions and synapses, for cell-cell communication. Here, we present recent advances in the understanding of thin membrane bridges that function in cell-cell signaling and intercellular transport. Cytonemes or filopodial bridges connect neighboring cells via mechanisms of adhesion, which enable ligand-receptor-mediated transfer of surface-associated cargoes from cell to cell. By contrast, tunneling nanotubes establish tubular conduits between cells that provide for the exchange of both cell-surface molecules and cytoplasmic content. We propose models for the biogenesis of both types of membrane bridges and describe how viruses use these structures for the purpose of cell-to-cell spread.
语言:: eng
DOI:

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