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PMID: 18701469 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Tumors sound the alarmin(s).

Cancer research ·Vol. 68 ·No. 16 ·2008-08-15 ·Pages 6482-5

Coffelt SB, Scandurro AB

Abstract

Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins-including the defensins, LL-37, and HMGB1-in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors.

MeSH Terms
Antimicrobial Cationic Peptides/metabolism Defensins/metabolism HMGB1 Protein/metabolism Humans Immune System Neoplasms/metabolism,pathology
Chemicals
Antimicrobial Cationic Peptides Defensins HMGB1 Protein ropocamptide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Coffelt Seth B
Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, USA.
Scandurro Aline B
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25 references, click to expand
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Article Info
Journal
Cancer research
Abbr.
Cancer Res
ISSN
1538-7445
DOI
10.1158/0008-5472.CAN-08-0044
Published
2008-08-15
Pages
6482-5
Language
English
Region
United States
NLM ID
2984705R
PMCID
PMC2755533
Subset
IM
Grants
NCRR NIH HHS · P20 RR020152-020005 · United States
NCRR NIH HHS · P20 RR020152 · United States
NCRR NIH HHS · P20 RR020152-037530 · United States
NCRR NIH HHS · 1P20RR20152-01 · United States
NCRR NIH HHS · P20 RR020152-047687 · United States
NCRR NIH HHS · P20 RR020152-056904 · United States
NCRR NIH HHS · P20 RR020152-010005 · United States
External Links
PubMed source DOI: 10.1158/0008-5472.CAN-08-0044 PMC Full Text View journal details
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