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PMID: 18701317 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Cytokines as a key component of cancer-related inflammation.

Cytokine ·Vol. 43 ·No. 3 ·2008-09-00 ·Pages 374-9

Germano G, Allavena P, Mantovani A

Abstract

Inflammatory conditions in some tissues increase the risk of cancer. Cytokines and chemokines are components of an intensive dialog promoting angiogenesis, metastasis, subversion of adaptive immunity and changing response to hormones and to chemotherapeutic agents. Cytokines involved in cancer-related inflammation represent a target for innovative diagnostic and therapeutic strategies, and a future challenge for scientists and clinicians.

MeSH Terms

Chemokines/physiology Cytokines/antagonists & inhibitors,physiology Humans Inflammation/etiology Interleukin-1/physiology Interleukin-6/physiology Neoplasms/physiopathology Neovascularization, Pathologic Receptors, Interleukin-1/physiology Tumor Necrosis Factor-alpha/physiology

Chemicals

Chemokines Cytokines Interleukin-1 Interleukin-6 Receptors, Interleukin-1 Tumor Necrosis Factor-alpha

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Germano Giovanni

Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy.

Allavena Paola

Mantovani Alberto

Article Info

Journal

Cytokine

Abbr.

Cytokine

ISSN

1096-0023

DOI

10.1016/j.cyto.2008.07.014

Published

2008-09-00

Epub

2008-00-12

Pages

374-9

Language

English

Region

England

NLM ID

9005353

Subset

External Links

PubMed source DOI: 10.1016/j.cyto.2008.07.014 View journal details

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