Home LiteratureArticle Details
PMID: 18687947 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Comment

Structural biology. Symmetric transporters for asymmetric transport.

Science (New York, N.Y.) ·Vol. 321 ·No. 5890 ·2008-08-08 ·Pages 781-2

Karpowich NK, Wang DN

Abstract

暂无摘要

MeSH Terms
Bacterial Proteins/chemistry,metabolism Binding Sites Cell Membrane/metabolism Galactose/metabolism Glucose/metabolism Humans Hydrophobic and Hydrophilic Interactions Intestinal Absorption Intestinal Mucosa/metabolism Kidney/metabolism Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Sodium/metabolism Sodium-Glucose Transport Proteins/chemistry,metabolism Sodium-Glucose Transporter 1/metabolism Sodium-Glucose Transporter 2/metabolism Vibrio parahaemolyticus/chemistry,metabolism
Chemicals
Bacterial Proteins Sodium-Glucose Transport Proteins Sodium-Glucose Transporter 1 Sodium-Glucose Transporter 2 sodium glucose symporter, Vibrio parahaemolyticus Sodium Glucose Galactose
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Karpowich Nathan K
Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA. karpowic@saturn.med.nyu.edu
Wang Da-Neng
References (12)
12 references, click to expand
  1. Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.
    Nature. 2007 Aug 23;448(7156):952-6 PMID: 17687333
  2. Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coli.
    Science. 2003 Aug 1;301(5633):616-20 PMID: 12893936
  3. Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters.
    Nature. 2005 Sep 8;437(7056):215-23 PMID: 16041361
  4. Structure and mechanism of the lactose permease of Escherichia coli.
    Science. 2003 Aug 1;301(5633):610-5 PMID: 12893935
  5. A GABA transporter operates asymmetrically and with variable stoichiometry.
    Neuron. 1994 Oct;13(4):949-60 PMID: 7524562
  6. Structure of a glutamate transporter homologue from Pyrococcus horikoshii.
    Nature. 2004 Oct 14;431(7010):811-8 PMID: 15483603
  7. LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake.
    Science. 2007 Sep 7;317(5843):1390-3 PMID: 17690258
  8. Membrane topology motifs in the SGLT cotransporter family.
    J Membr Biol. 1997 Sep 1;159(1):1-20 PMID: 9309206
  9. Passive water and ion transport by cotransporters.
    J Physiol. 1999 Jul 1;518(Pt 1):195-202 PMID: 10373701
  10. The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.
    Mol Cell. 2008 Jun 20;30(6):667-77 PMID: 18570870
  11. Ligand conduction and the gated-pore mechanism of transmembrane transport.
    Biochim Biophys Acta. 1997 Nov 21;1331(3):213-34 PMID: 9512653
  12. Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside.
    Nature. 2003 Nov 6;426(6962):39-44 PMID: 14603310
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1161495
Email
karpowic@saturn.med.nyu.edu
Published
2008-08-08
Pages
781-2
Language
English
Region
United States
NLM ID
0404511
PMCID
PMC2630483
Subset
IM
Grants
NIGMS NIH HHS · R21 GM075936 · United States
NIGMS NIH HHS · R21 GM075936-02S1 · United States
NIDDK NIH HHS · R01 DK053973 · United States
NIGMS NIH HHS · GM075936 · United States
NIDDK NIH HHS · DK053973 · United States
NIGMS NIH HHS · U54 GM075026-040010 · United States
NIGMS NIH HHS · U54 GM075026 · United States
NIGMS NIH HHS · GM075026 · United States
NIMH NIH HHS · R01 MH083840-01 · United States
NIMH NIH HHS · MH083840 · United States
NIDDK NIH HHS · R01 DK053973-09 · United States
NIMH NIH HHS · R01 MH083840 · United States
Corrections
CommentOn
PMID: 18599740
External Links
PubMed source DOI: 10.1126/science.1161495 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2