Modification of actins by phallotoxins.

Die Naturwissenschaften ·Vol. 64 ·No. 6 ·1977-06-00 ·Pages 303-9

Wieland T

Abstract

Phallotoxins bind to filamentous actin (F-actin) from liver or rabbit muscle with Kdiss approximately 10(-8) M. By this combination the structure of F-actin is stabilized to such an extent that it will be resistant to the depolymerizing action of 0.6 M KI and of deoxyribonuclease I, to denaturation by heat (70 degrees C), and to local ruptures caused by ultrasonication or by cytochalasin B. The structural features of phallotoxins essential for affinity to F-actin are specific.

MeSH Terms

Actins/metabolism Animals Chemical Phenomena Chemistry Circular Dichroism Cytochalasin B/pharmacology Deoxyribonucleases/metabolism Hot Temperature Hydrogen-Ion Concentration Liver/metabolism Oligopeptides/analogs & derivatives Phalloidine/analogs & derivatives,toxicity Potassium/pharmacology Protein Binding Rats Sonication Spectrophotometry, Ultraviolet Structure-Activity Relationship

Chemicals

Actins Oligopeptides Phalloidine Cytochalasin B Deoxyribonucleases Potassium

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Wieland T

References (27)

27 references, click to expand

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Article Info

Journal

Die Naturwissenschaften

Abbr.

Naturwissenschaften

ISSN

0028-1042

DOI

10.1007/BF00446784

Published

1977-06-00

Pages

303-9

Language

English

Region

Germany

NLM ID

0400767

Subset

External Links

PubMed source DOI: 10.1007/BF00446784 View journal details

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Modification of actins by phallotoxins.

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