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题目:: JMV-1 stimulation of avian natural killer cell activity.
作者:: Keller(L H),Lillehoj(H S),Solnosky(J M)
状态:: 发布时间2008-08-01 , 更新时间 2008-08-01
期刊:: Avian Pathol
摘要:: The phenotypic characterization of the non-productive, Marek's disease virus-transformed, lymphoblastoid cell line, JMV-1 and the immunological effects of its cell-free culture supernatant were examined. It was verified that the JMV-1 cell line is an activated T-helper cell line that bears antigens indicative of T-cell activation, and it is not a natural killer or cytotoxic T-cell line. Furthermore, the JMV-1 cell line was shown to be unique among Marek's disease-transformed cell lines in that JMV-1 cells secrete factors that are able to stimulate in vitro natural killer cell cytotoxicity against the avian tumour cell line, LSCC-RP9, in a 4-h assay. Culturing spleen cells in the presence of JMV-1 supernatant for 4 h stimulates a significant increase in NK cell populations and in la-bearing cell populations, as detected by monoclonal antibody staining. These findings suggest that the protective effects against the parasitic and virally-induced lymphoproliferative poultry diseases, which have been credited to the JMV-1 cell line and to its cell-free culture supernatant, are in part due to lymphokine activation of NK cell cytotoxicity.
语言:: eng
DOI:: 10.1080/03079459208418839

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