The serum pepsinogen level with special reference to the histology of the gastric mucosa.

Gut ·Vol. 4 ·No. 2 ·1963-06-00 ·Pages 106-11

Bock OA, Arapakis G, Witts LJ, Richards WC

Abstract

Determination of the serum pepsinogen level is simple and the method gives consistent results. The serum pepsinogen level remains steady when the stomach is actively secreting pepsin. Age and sex do not greatly affect the serum pepsinogen concentration. Serum pepsinogen levels can be correlated with the histological appearances of the gastric mucosa. The parietal cells appear to be more sensitive to injury than the chief cells. The serum pepsinogen levels of patients with pernicious anaemia are very low. Estimation of the serum pepsinogen level is likely to prove a useful screening test for severe atrophic gastritis and gastric atrophy.

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Bock O A

Arapakis G

Witts L J

Richards W C

References (19)

19 references, click to expand

Blood plasma pepsinogen. I. The source, properties, and assay of the proteolytic activity of plasma at acid reactions.
J Lab Clin Med. 1952 Jul;40(1):17-26 PMID: 14938744
Gastric atrophy, atrophic gastritis, and gastric secretory failure. Correlative study by suction biopsy and exfoliative cytology of gastric mucosa, paper electrophoretic and secretory assays of gastric secretion, and measurements of intestinal absorption and blood levels of vitamin B12.
Gastroenterology. 1960 Oct;39:429-53 PMID: 13705942
Serum pepsinogen levels: relation to gastric secretion and gastric biopsy.
Med J Aust. 1958 Dec 20;45(25):831-3 PMID: 13612486
Interrelationship of acid, pepsin, and intrinsic factor production: an indirect gastric secretory study.
Gastroenterology. 1959 Aug;37:182-7 PMID: 14446548
The independent secretion of acid, pepsin, and intrinsic factor by the human stomach.
Gastroenterology. 1958 Feb;34(2):196-209 PMID: 13512593
Pepsinogen in the blood.
J Lab Clin Med. 1955 Oct;46(4):568-79 PMID: 13263737
Serum and urine pepsinogen and gastric pepsin; simultaneous analyses for 24-hour periods in normal persons and in patients with duodenal ulcer, gastric ulcer and achlorhydria.
Gastroenterology. 1958 Mar;34(3):421-35 PMID: 13512613
Indirect gastric secretory studies; a comparison of tubeless gastric analysis and plasma pepsinogen determination as screening procedures.
Am J Dig Dis. 1957 Jul;2(7):363-76 PMID: 13444229
Blood plasma pepsinogen. II. The activity of the plasma from normal subjects, patients with duodenal ulcer, and patients with pernicious anemia.
J Lab Clin Med. 1952 Aug;40(2):188-99 PMID: 14946456
Value of plasma pepsinogen estimation.
Br Med J. 1960 Jan 2;1(5165):30-2 PMID: 13819421
Superficial gastritis; a cause of temporary achlorhydria and hyperpepsinemia.
N Engl J Med. 1958 Oct 2;259(14):682-4 PMID: 13590425
Effect of large doses of histamine on gastric secretion of HCI; an augmented histamine test.
Br Med J. 1953 Jul 11;2(4827):77-80 PMID: 13051582
The relationship between acid secretion after augmented histamine stimulation and the histology of the gastric mucosa.
Gut. 1963 Jun;4(2):112-4 PMID: 18668757
Diagnostic value of a single plasma pepsinogen estimation. An assessment in 500 cases.
Br Med J. 1962 May 26;1(5290):1453-4 PMID: 13925777
Plasma pepsinogen in peptic-ulcer disease and other gastric disorders; a clinical and laboratory evaluation.
N Engl J Med. 1956 Jul 26;255(4):153-8 PMID: 13348830
The gastric secretion of pepsin in man.
Gut. 1962 Sep;3:255-9 PMID: 13947905
Studies on a blood serum proteolytic enzyme with particular reference to gastric secretory function.
Gastroenterology. 1953 Sep;25(1):14-23 PMID: 13095670
The relation of blood pepsin to gastric secretion, with particular reference to anacidity and achylia.
Gastroenterology. 1956 Apr;30(4):563-79; discussion, 580-2 PMID: 13318236
Serial gastric biopsy studies in a case of duodenal ulcer treated by deep x-ray therapy.
Med J Aust. 1951 Jun 9;1(23):828-30 PMID: 14852197

Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.4.2.106

Published

1963-06-00

Pages

106-11

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1413432

External Links

PubMed source DOI: 10.1136/gut.4.2.106 PMC Full Text View journal details

Analysis Services

The serum pepsinogen level with special reference to the histology of the gastric mucosa.

Contact

WeChat Official Account