Gastric acid secretion and mucosal appearances in Addison's disease and hypopituitarism.

Gut ·Vol. 2 ·No. 2 ·1961-06-00 ·Pages 163-7

Smith AW, Delamore IW, Williams AW

Abstract

Studies of gastric acid secretion and mucosal appearances have been made in a group of 14 patients suffering from hypopituitarism. Achlorhydria was found in six of the patients suffering from Addison's disease but in only one patient suffering from hypopituitarism. In both groups the mean gastric secretion of hydrochloric acid was considerably lower than in a group of control subjects and replacement therapy with cortisone and DOCA in Addison's disease and cortisone and thyroid extract in hypopituitarism failed to restore gastric function to normal. A constant correlation was not found between gastric acid secretion and mucosal appearances.

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Smith A W

Delamore I W

Williams A W

References (14)

14 references, click to expand

Effects of ACTH and cortisone upon the stomach: its significance in the normal and in peptic ulcer.
Gastroenterology. 1951 Dec;19(4):658-73 PMID: 14897066
[Stomach changes in Addison's disease].
Dtsch Med Wochenschr. 1952 Sep 26;77(39):1173-5 PMID: 12979784
Effect of hypophysectomy on the cytology of the fundic glands of the stomach and on the secretion of pepsin.
Am J Physiol. 1954 Jun;177(3):409-12 PMID: 13158584
The histamine response of the gastric mucosa in a patient with adrenal insufficiency: effect of cortisone administration.
Gastroenterology. 1954 Sep;27(3):358-62 PMID: 13200722
Effects of cortisone and of adrenalectomy of secretion of gastric acid and on occurrence of gastric ulceration in the pylorus-ligated rat.
Gastroenterology. 1953 Mar;23(3):356-62 PMID: 13034020
Intraluminal biopsy of the small intestine; the intestinal biopsy capsule.
Am J Dig Dis. 1957 May;2(5):236-41 PMID: 13410880
Addison's disease.
Medicine (Baltimore). 1949 Dec;28(4):371-425 PMID: 15408533
Unfavorable course of gastric ulcer during administration of ACTH and cortisone.
Gastroenterology. 1952 Jan;20(1):27-9 PMID: 14897084
The relationship between the acid output of the stomach following "maximal" histamine stimulation and the parietal cell mass.
Clin Sci. 1960 Feb;19:147-63 PMID: 13807647
Atrophy of the gastrointestinal mucosa following hypophysectomy or adrenalectomy.
Acta Physiol Scand Suppl. 1953;111:161-9 PMID: 13147962
A modification of Zimmermann's method for differential staining of gastric mucosa.
Stain Technol. 1957 Jan;32(1):48 PMID: 13391330
The histology of the gastro-intestinal mucosa (rat) after adrenalectomy or administration of adrenocortical hormones.
Am J Anat. 1954 May;94(3):363-97 PMID: 13171340
The response to different regions of the gastrointestinal tract to normal and abnormal stimuli; influence of feeding inert bulk material and of hypophysectomy.
J Natl Cancer Inst. 1953 Feb;13(4):1035-8 PMID: 13035433
Effect of large doses of histamine on gastric secretion of HCI; an augmented histamine test.
Br Med J. 1953 Jul 11;2(4827):77-80 PMID: 13051582

Article Info

Journal

Gut

Abbr.

Gut

ISSN

0017-5749

DOI

10.1136/gut.2.2.163

Published

1961-06-00

Pages

163-7

Language

English

Region

England

NLM ID

2985108R

PMCID

PMC1413244

External Links

PubMed source DOI: 10.1136/gut.2.2.163 PMC Full Text View journal details

Analysis Services

Gastric acid secretion and mucosal appearances in Addison's disease and hypopituitarism.

Contact

WeChat Official Account