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PMID: 18655795 Published · ppublish English Journal Article Review

A nomenclature for ligand-gated ion channels.

Neuropharmacology ·Vol. 56 ·No. 1 ·2009-01-00 ·Pages 2-5

Collingridge GL, Olsen RW, Peters J, Spedding M

Abstract

The ligand-gated ion channels that participate in fast synaptic transmission comprise the nicotinic acetylcholine, 5-hydroxytryptamine3 (5-HT3), gamma-aminobutyric acidA (GABA(A)), glycine, ionotropic glutamate and P2X receptor families. A consistent and systematic nomenclature for the individual subunits that comprise these receptors and the receptors that result from their co-assembly is highly desirable. There is also a need to develop criteria that aid in deciding which of the vast number of heteromeric combinations of subunits that can be assembled in heterologous expression systems in vitro, are known, or likely, to exist as functional receptors in vivo. The aim of this short article is to summarize the progress being made by the nomenclature committee of IUPHAR (NC-IUPHAR) in formulating recommendations that attempt to address these issues.

MeSH Terms
Animals Ion Channel Gating/physiology Ion Channels/classification,physiology Terminology as Topic
Chemicals
Ion Channels
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Collingridge Graham L
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK. g.l.collingridge@bristol.ac.uk
Olsen Richard W
Peters John
Spedding Michael
References (22)
22 references, click to expand
  1. International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.
    Pharmacol Rev. 2001 Mar;53(1):107-18 PMID: 11171941
  2. Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant.
    J Biol Chem. 1994 Jan 28;269(4):2607-12 PMID: 7507926
  3. The history of the pharmacology and cloning of ionotropic glutamate receptors and the development of idiosyncratic nomenclature.
    Neuropharmacology. 2009 Jan;56(1):6-21 PMID: 18765242
  4. Molecular cloning and characterization of the rat NMDA receptor.
    Nature. 1991 Nov 7;354(6348):31-7 PMID: 1834949
  5. International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.
    Pharmacol Rev. 2005 Dec;57(4):509-26 PMID: 16382105
  6. Analysis of the set of GABA(A) receptor genes in the human genome.
    J Biol Chem. 2004 Oct 1;279(40):41422-35 PMID: 15258161
  7. Molecular cloning and functional expression of glutamate receptor subunit genes.
    Science. 1990 Aug 31;249(4972):1033-7 PMID: 2168579
  8. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.
    Pharmacol Rev. 2005 Dec;57(4):527-40 PMID: 16382106
  9. International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.
    Pharmacol Rev. 2005 Dec;57(4):473-508 PMID: 16382104
  10. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
    Pharmacol Rev. 1998 Jun;50(2):291-313 PMID: 9647870
  11. International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.
    Pharmacol Rev. 2005 Dec;57(4):455-62 PMID: 16382102
  12. Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs.
    Nature. 1992 May 7;357(6373):70-4 PMID: 1374164
  13. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.
    Pharmacol Rev. 2005 Dec;57(4):427-50 PMID: 16382100
  14. The glutamate story.
    Br J Pharmacol. 2006 Jan;147 Suppl 1:S100-8 PMID: 16402093
  15. A family of AMPA-selective glutamate receptors.
    Science. 1990 Aug 3;249(4968):556-60 PMID: 2166337
  16. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.
    Pharmacol Rev. 2005 Dec;57(4):411-25 PMID: 16382099
  17. Cloning of a novel glutamate receptor subunit, GluR5: expression in the nervous system during development.
    Neuron. 1990 Nov;5(5):583-95 PMID: 1977421
  18. International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.
    Pharmacol Rev. 2005 Dec;57(4):463-72 PMID: 16382103
  19. Brain alpha-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily.
    Neuron. 1990 Jul;5(1):35-48 PMID: 2369519
  20. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).
    Pharmacol Rev. 1994 Jun;46(2):157-203 PMID: 7938165
  21. International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits.
    Pharmacol Rev. 1999 Jun;51(2):397-401 PMID: 10353988
  22. International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update.
    Pharmacol Rev. 2008 Sep;60(3):243-60 PMID: 18790874
Article Info
Journal
Neuropharmacology
Abbr.
Neuropharmacology
ISSN
0028-3908
DOI
10.1016/j.neuropharm.2008.06.063
Email
g.l.collingridge@bristol.ac.uk
Published
2009-01-00
Epub
2008-00-04
Pages
2-5
Language
English
Region
England
NLM ID
0236217
PMCID
PMC2847504
Subset
IM
Grants
NIGMS NIH HHS · P01 GM058448-040004 · United States
NINDS NIH HHS · P01 NS035985 · United States
Medical Research Council · G0601813 · United Kingdom
NIAAA NIH HHS · R01 AA007680 · United States
NIGMS NIH HHS · P01 GM058448 · United States
NINDS NIH HHS · P01 NS035985-080001 · United States
NIAAA NIH HHS · R01 AA007680-17A1 · United States
External Links
PubMed source DOI: 10.1016/j.neuropharm.2008.06.063 PMC Full Text View journal details
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