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PMID: 18651793 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Spinal cord injury reveals multilineage differentiation of ependymal cells.

PLoS biology ·Vol. 6 ·No. 7 ·2008-07-22 ·Pages e182

Meletis K, Barnabé-Heider F, Carlén M, Evergren E, Tomilin N, Shupliakov O, Frisén J

Abstract

Spinal cord injury often results in permanent functional impairment. Neural stem cells present in the adult spinal cord can be expanded in vitro and improve recovery when transplanted to the injured spinal cord, demonstrating the presence of cells that can promote regeneration but that normally fail to do so efficiently. Using genetic fate mapping, we show that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal. These cells are recruited by spinal cord injury and produce not only scar-forming glial cells, but also, to a lesser degree, oligodendrocytes. Modulating the fate of ependymal progeny after spinal cord injury may offer an alternative to cell transplantation for cell replacement therapies in spinal cord injury.

MeSH Terms
Animals Cell Differentiation Cell Lineage Cell Movement Ependyma/pathology Mice Neuroglia/pathology Neurons/pathology,physiology Spinal Cord Injuries/pathology Stem Cells/pathology,physiology
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Meletis Konstantinos
Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Barnabé-Heider Fanie
Carlén Marie
Evergren Emma
Tomilin Nikolay
Shupliakov Oleg
Frisén Jonas
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Article Info
Journal
PLoS biology
Abbr.
PLoS Biol
ISSN
1545-7885
DOI
10.1371/journal.pbio.0060182
Published
2008-07-22
Pages
e182
Language
English
Region
United States
NLM ID
101183755
PMCID
PMC2475541
Subset
IM
External Links
PubMed source DOI: 10.1371/journal.pbio.0060182 PMC Full Text View journal details
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