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PMID: 18632554 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Modular networks and cumulative impact of lateral transfer in prokaryote genome evolution.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 105 ·No. 29 ·2008-07-22 ·Pages 10039-44

Dagan T, Artzy-Randrup Y, Martin W

Abstract

Lateral gene transfer is an important mechanism of natural variation among prokaryotes, but the significance of its quantitative contribution to genome evolution is debated. Here, we report networks that capture both vertical and lateral components of evolutionary history among 539,723 genes distributed across 181 sequenced prokaryotic genomes. Partitioning of these networks by an eigenspectrum analysis identifies community structure in prokaryotic gene-sharing networks, the modules of which do not correspond to a strictly hierarchical prokaryotic classification. Our results indicate that, on average, at least 81 +/- 15% of the genes in each genome studied were involved in lateral gene transfer at some point in their history, even though they can be vertically inherited after acquisition, uncovering a substantial cumulative effect of lateral gene transfer on longer evolutionary time scales.

MeSH Terms
Archaea/genetics Bacteria/genetics Bacterial Proteins/genetics Biological Evolution Gene Regulatory Networks Gene Transfer, Horizontal Genome, Archaeal Genome, Bacterial Models, Genetic Phylogeny Prokaryotic Cells
Chemicals
Bacterial Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dagan Tal
Institut für Botanik III, Heinrich-Heine Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany. tal.dagan@uni-duesseldorf.de
Artzy-Randrup Yael
Martin William
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.0800679105
Email
tal.dagan@uni-duesseldorf.de
Published
2008-07-22
Epub
2008-00-16
Pages
10039-44
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC2474566
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.0800679105 PMC Full Text View journal details
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