| GeneLibs

题目:: Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia.
作者:: Stuart Gibbons(Andrew),Scarr(Elizabeth),McOmish(Caitlin E),Hannan(Anthony J),Thomas(Elizabeth A),Dean(Brian)
状态:: 发布时间2008-07-14 , 更新时间 2009-11-11
期刊:: Aust N Z J Psychiatry
摘要:: Regulator of G-protein signalling 4 (RGS4) modulates signal transduction through several neurotransmitter receptor systems associated with the pathology of schizophrenia. A reported decrease in RGS4 expression in the prefrontal cortex of schizophrenia patients followed by supporting evidence from association studies implicated RGS4 as a susceptibility gene for schizophrenia. Subsequent efforts to extend these findings in post-mortem brain tissue have produced conflicting results. The aim of the present study was to reconcile these discrepancies by examining RGS4 expression in the dorsolateral prefrontal and parietal cortices from subjects with schizophrenia.,RGS4 mRNA and protein levels were measured in post-mortem Brodmann area (BA)9 and BA40 tissue from 19 schizophrenia patients subjects and 19 pair-matched controls using in situ hybridization and western blotting.,Levels of RGS4 mRNA (F(1,73)=1.845; p >0.05) or protein (F(1,72)=3.336 x 10(-4), p >0.05) did not vary significantly with diagnosis in BA9 or BA40 from subjects with schizophrenia.,Altered RGS4 expression is not universally present throughout the cortex of people with schizophrenia.
语言:: eng
DOI:: 10.1080/00048670802206338

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息