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PMID: 1861720 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Multiple modes of engrailed regulation in the progression towards cell fate determination.

Nature ·Vol. 352 ·No. 6334 ·1991-08-01 ·Pages 404-10

Heemskerk J, DiNardo S, Kostriken R, O'Farrell PH

Abstract

The engrailed gene product of Drosophila specifies the fate of a subset of cells in each segment. Our studies of engrailed regulation suggest that fate determination is an elaborate, multistep process. At the time in embryogenesis when the engrailed-dependent cell fate is probably determined, four modes of control act in an overlapping progression to govern engrailed expression. After activation by pair-rule genes, both an extracellular signal, wingless, and autoregulation are required for engrailed expression. Autoregulation graduates to wingless independence, but is transient, and is superseded by an engrailed-independent mode of maintenance.

Related Genes
en wg
MeSH Terms
Animals Cell Differentiation/genetics Drosophila/embryology,genetics Ectoderm/cytology Gene Expression Regulation Homeostasis Hot Temperature Mutation Promoter Regions, Genetic Stem Cells/cytology Wings, Animal/embryology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Heemskerk J
Department of Biochemistry and Biophysics, UCSF School of Medicine 94143-0448.
DiNardo S
Kostriken R
O'Farrell P H
References (30)
30 references, click to expand
  1. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless.
    Cell. 1987 Aug 14;50(4):649-57 PMID: 3111720
  2. Transposition of cloned P elements into Drosophila germ line chromosomes.
    Science. 1982 Oct 22;218(4570):341-7 PMID: 6289435
  3. Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila.
    EMBO J. 1985 Dec 1;4(12):3259-64 PMID: 2419125
  4. Modifying expression of the engrailed gene of Drosophila melanogaster.
    Development. 1988;104 Suppl:85-93 PMID: 3151689
  5. The engrailed locus of Drosophila: structural analysis of an embryonic transcript.
    Cell. 1985 Jan;40(1):37-43 PMID: 3917855
  6. Engrailed: a gene controlling compartment and segment formation in Drosophila.
    Proc Natl Acad Sci U S A. 1981 Feb;78(2):1095-9 PMID: 6821526
  7. Localization of transcripts from the wingless gene in whole Drosophila embryos.
    Development. 1988 Jun;103(2):289-98 PMID: 3224555
  8. Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm.
    Cell. 1986 Mar 28;44(6):949-57 PMID: 3955654
  9. Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos.
    EMBO J. 1987 Jun;6(6):1765-73 PMID: 16453776
  10. Compartments in the wing of Drosophila: a study of the engrailed gene.
    Dev Biol. 1976 Jun;50(2):321-37 PMID: 1278589
  11. Developmental compartmentalization in the dorsal mesothoracic disc of Drosophila.
    Dev Biol. 1976 Jan;48(1):132-47 PMID: 1245256
  12. Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair-rule genes.
    Genes Dev. 1987 Dec;1(10):1212-25 PMID: 3123316
  13. Developmental compartmentalisation of the wing disk of Drosophila.
    Nat New Biol. 1973 Oct 24;245(147):251-3 PMID: 4518369
  14. Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila.
    Cell. 1986 Mar 14;44(5):739-48 PMID: 3081265
  15. Autoregulatory functioning of a Drosophila gene product that establish es and maintains the sexually determined state.
    Genetics. 1984 Jun;107(2):231-77 PMID: 6735170
  16. Distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication.
    Cell. 1989 Nov 17;59(4):739-49 PMID: 2582493
  17. polyhomeotic: a gene required for the embryonic development of axon pathways in the central nervous system of Drosophila.
    Genes Dev. 1988 Jul;2(7):830-42 PMID: 2905316
  18. Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo.
    Development. 1988 May;103(1):157-70 PMID: 3197626
  19. Autoregulation of a Drosophila homeotic selector gene.
    Cell. 1988 Nov 4;55(3):477-85 PMID: 2902926
  20. The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression.
    Cell. 1985 Jan;40(1):45-53 PMID: 3917856
  21. Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein.
    Cell. 1985 Nov;43(1):59-69 PMID: 3935318
  22. Tissue- and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene.
    Development. 1988 Aug;103(4):733-41 PMID: 2907878
  23. Genetic control of wing disc development in Drosophila.
    Ciba Found Symp. 1975;0(29):161-82 PMID: 1039909
  24. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback.
    Chromosoma. 1989 Aug;98(2):81-5 PMID: 2476281
  25. Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila.
    Dev Biol. 1988 Jan;125(1):96-108 PMID: 3119404
  26. Positive autoregulation of the myogenic determination gene MyoD1.
    Cell. 1989 Jul 28;58(2):241-8 PMID: 2546677
  27. Active repression of transcription by the engrailed homeodomain protein.
    EMBO J. 1991 Jun;10(6):1427-33 PMID: 1673924
  28. The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains.
    Proc Natl Acad Sci U S A. 1990 Mar;87(6):2112-6 PMID: 2107543
  29. Spatial and temporal control elements of the Drosophila engrailed gene.
    Genes Dev. 1990 Mar;4(3):433-43 PMID: 2110923
  30. Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis.
    Development. 1988 Dec;104(4):713-20 PMID: 2908325
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/352404a0
Published
1991-08-01
Pages
404-10
Language
English
Region
England
NLM ID
0410462
PMCID
PMC2755087
Subset
IM
Grants
NIGMS NIH HHS · R01 GM037193 · United States
NIGMS NIH HHS · R01 GM037193-10 · United States
External Links
PubMed source DOI: 10.1038/352404a0 PMC Full Text View journal details
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