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PMID: 18616967 Published · ppublish English Journal Article Review

The Genome Sequencer FLX System--longer reads, more applications, straight forward bioinformatics and more complete data sets.

Journal of biotechnology ·Vol. 136 ·No. 1-2 ·2008-08-31 ·Pages 3-10

Droege M, Hill B

Abstract

The Genome Sequencer FLX System (GS FLX), powered by 454 Sequencing, is a next-generation DNA sequencing technology featuring a unique mix of long reads, exceptional accuracy, and ultra-high throughput. It has been proven to be the most versatile of all currently available next-generation sequencing technologies, supporting many high-profile studies in over seven applications categories. GS FLX users have pursued innovative research in de novo sequencing, re-sequencing of whole genomes and target DNA regions, metagenomics, and RNA analysis. 454 Sequencing is a powerful tool for human genetics research, having recently re-sequenced the genome of an individual human, currently re-sequencing the complete human exome and targeted genomic regions using the NimbleGen sequence capture process, and detected low-frequency somatic mutations linked to cancer.

MeSH Terms
Algorithms Base Sequence Chromosome Mapping/methods Computational Biology/methods Database Management Systems Databases, Genetic Molecular Sequence Data Sequence Analysis, DNA/methods Software Software Design User-Computer Interface
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Droege Marcus
Roche Applied Science, Global Marketing, 82372 Penzberg, Germany. Marcus.Droege@Roche.com
Hill Brendon
Article Info
Journal
Journal of biotechnology
Abbr.
J Biotechnol
ISSN
0168-1656
Published
2008-08-31
Epub
2008-00-21
Pages
3-10
Language
English
Region
Netherlands
NLM ID
8411927
Subset
IM
Analysis Services
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