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PMID: 18614774 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Macrophage stimulating protein may promote tubular regeneration after acute injury.

Journal of the American Society of Nephrology : JASN ·Vol. 19 ·No. 10 ·2008-10-00 ·Pages 1904-18

Cantaluppi V, Biancone L, Romanazzi GM, Figliolini F, Beltramo S, Galimi F, Camboni MG, Deriu E, Conaldi P, Bottelli A, Orlandi V, Herrera MB, Pacitti A, Segoloni GP, Camussi G

Abstract

Macrophage-stimulating protein (MSP) exerts proliferative and antiapoptotic effects, suggesting that it may play a role in tubular regeneration after acute kidney injury. In this study, elevated plasma levels of MSP were found both in critically ill patients with acute renal failure and in recipients of renal allografts during the first week after transplantation. In addition, MSP and its receptor, RON, were markedly upregulated in the regenerative phase after glycerol-induced tubular injury in mice. In vitro, MSP stimulated tubular epithelial cell proliferation and conferred resistance to cisplatin-induced apoptosis by inhibiting caspase activation and modulating Fas, mitochondrial proteins, Akt, and extracellular signal-regulated kinase. MSP also enhanced migration, scattering, branching morphogenesis, tubulogenesis, and mesenchymal de-differentiation of surviving tubular cells. In addition, MSP induced an embryonic phenotype characterized by Pax-2 expression. In conclusion, MSP is upregulated during the regeneration of injured tubular cells, and it exerts multiple biologic effects that may aid recovery from acute kidney injury.

MeSH Terms
Acute Kidney Injury/blood Aged Animals Case-Control Studies Cell Culture Techniques Cell Survival Critical Illness Hepatocyte Growth Factor/blood Humans Kidney Transplantation Kidney Tubules/physiology Mice Mice, Inbred C57BL Middle Aged Proto-Oncogene Proteins/blood Receptor Protein-Tyrosine Kinases/blood Regeneration/physiology
Chemicals
Proto-Oncogene Proteins macrophage stimulating protein Hepatocyte Growth Factor RON protein Receptor Protein-Tyrosine Kinases
Authors & Affiliations
15 authors, click to expand affiliations / ORCID
Cantaluppi Vincenzo
Research Center for Experimental Medicine, Department of Internal Medicine, University of Torino, Torino, Italy.
Biancone Luigi
Romanazzi Giuseppe Mauriello
Figliolini Federico
Beltramo Silvia
Galimi Francesco
Camboni Maria Gavina
Deriu Elisa
Conaldi Piergiulio
Bottelli Antonella
Orlandi Viviana
Herrera Maria Beatriz
Pacitti Alfonso
Segoloni Giuseppe Paolo
Camussi Giovanni
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Article Info
Journal
Journal of the American Society of Nephrology : JASN
Abbr.
J Am Soc Nephrol
ISSN
1533-3450
DOI
10.1681/ASN.2007111209
Published
2008-10-00
Epub
2008-00-09
Pages
1904-18
Language
English
Region
United States
NLM ID
9013836
PMCID
PMC2551565
Subset
IM
Corrections
CommentIn
PMID: 21997395
External Links
PubMed source DOI: 10.1681/ASN.2007111209 PMC Full Text View journal details
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