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PMID: 18606126 Published · ppublish English Comment Journal Article

RNA interference: endogenous siRNAs derived from transposable elements.

Current biology : CB ·Vol. 18 ·No. 13 ·2008-07-08 ·Pages R561-3

Obbard DJ, Finnegan DJ

Abstract

The Piwi-interacting RNA interference pathway plays an important role in suppressing transposable elements in the Drosophila germline. Now, deep sequencing of short RNAs from somatic tissue and cell culture has identified a novel class of endogenous siRNAs that may have a similar role in the soma.

MeSH Terms
Animals Argonaute Proteins DNA Transposable Elements Drosophila/metabolism Drosophila Proteins Proteins/metabolism RNA Interference RNA, Small Interfering/metabolism RNA-Induced Silencing Complex
Chemicals
Argonaute Proteins DNA Transposable Elements Drosophila Proteins Proteins RNA, Small Interfering RNA-Induced Silencing Complex piwi protein, Drosophila
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Obbard Darren J
Institute of Evolutionary Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK.
Finnegan David J
Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
DOI
10.1016/j.cub.2008.05.035
Published
2008-07-08
Pages
R561-3
Language
English
Region
England
NLM ID
9107782
Subset
IM
Corrections
CommentOn
PMID: 18501606
External Links
PubMed source DOI: 10.1016/j.cub.2008.05.035 View journal details
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