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PMID: 18599363 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

Cell metabolism ·Vol. 8 ·No. 2 ·2008-08-00 ·Pages 157-68

Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R

Abstract

A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.

MeSH Terms
Age Factors Aging/drug effects,genetics,metabolism Animals Antioxidants/pharmacology,therapeutic use Apoptosis/drug effects,physiology Caloric Restriction Cardiovascular System/drug effects,physiopathology Energy Intake/genetics Food Deprivation/physiology Food, Formulated Gene Expression Regulation/drug effects,genetics Inflammation/drug therapy,prevention & control Longevity/drug effects,genetics Male Mice Mice, Inbred C57BL Osteoporosis/drug therapy,prevention & control Resveratrol Stilbenes/pharmacology,therapeutic use Transcription, Genetic/drug effects,genetics Treatment Outcome
Chemicals
Antioxidants Stilbenes Resveratrol
Authors & Affiliations
27 authors, click to expand affiliations / ORCID
Pearson Kevin J
Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.
Baur Joseph A
Lewis Kaitlyn N
Peshkin Leonid
Price Nathan L
Labinskyy Nazar
Swindell William R
Kamara Davida
Minor Robin K
Perez Evelyn
Jamieson Hamish A
Zhang Yongqing
Dunn Stephen R
Sharma Kumar
Pleshko Nancy
Woollett Laura A
Csiszar Anna
Ikeno Yuji
Le Couteur David
Elliott Peter J
Becker Kevin G
Navas Placido
Ingram Donald K
Wolf Norman S
Ungvari Zoltan
Sinclair David A
de Cabo Rafael
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Article Info
Journal
Cell metabolism
Abbr.
Cell Metab
ISSN
1932-7420
Published
2008-08-00
Epub
2008-00-03
Pages
157-68
Language
English
Region
United States
NLM ID
101233170
PMCID
PMC2538685
Subset
IM
Grants
NIA NIH HHS · R01 AG019972-03 · United States
NHLBI NIH HHS · R01 HL077256 · United States
NICHD NIH HHS · HD034089 · United States
NICHD NIH HHS · R01 HD034089 · United States
NEI NIH HHS · 2R01EY011733 · United States
NIGMS NIH HHS · R01 GM068072 · United States
NIA NIH HHS · R01 AG019972 · United States
NICHD NIH HHS · R56 HD034089 · United States
NIA NIH HHS · R01 AG028730-01A1 · United States
NIA NIH HHS · AG19972 · United States
NIA NIH HHS · AG19719 · United States
NIA NIH HHS · R01 AG019719 · United States
Intramural NIH HHS · Z01 AG000368-03 · United States
NIDDK NIH HHS · SP30DK072437 · United States
NIA NIH HHS · R01 AG028730 · United States
NHLBI NIH HHS · HL077256 · United States
NEI NIH HHS · R01 EY011733 · United States
NIGMS NIH HHS · R01GM068072 · United States
NIGMS NIH HHS · R01 GM068072-01 · United States
NIAMS NIH HHS · P30 AR046121 · United States
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