A novel role for a familiar protein in apoptosis induced by proteasome inhibition.
作者:
McConkey(David J)
状态:
发布时间2008-07-07
, 更新时间 2015-11-19
期刊:
Cancer Cell
摘要:
In this issue of Cancer Cell, Nickeleit et al. (2008) identify a new proteasome inhibitor, argyrin A, and show that it induces apoptosis and inhibits angiogenesis via p27-dependent mechanisms. Their observations challenge current thinking about how this class of promising cancer therapies works and why they selectively kill cancer cells.