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题目:: CD7(-) T cells are late memory cells generated from CD7(+) T cells.
作者:: Rappl(Gunter),Schrama(David),Hombach(Andreas),Meuer(Eva Katharina),Schmidt(Annette),Becker(Jürgen C),Abken(Hinrich)
状态:: 发布时间2008-07-02 , 更新时间 2008-07-02
期刊:: Rejuvenation Res
摘要:: CD7(-) T cells constitute a distinct subset within the CD4(+) and CD8(+) T cell populations; their developmental and functional relationship to the majority of CD7(+) T cells, however, remained so far unresolved. We here elucidate that CD7(-) cells represent aging T cells in late memory cell development characterized by a high activation threshold, low effector capacities, and high sensitivity to activation-induced cell death (AICD). In this regard, CD7(-) T cells highly express killer cell lectin-like receptor G1 (KLRG-1), harbor telomeres of shorter lengths, a decreased telomerase expression per cell, and less amounts of T cell receptor rearrangement excision circles (TRECs) compared to CD7(+) cells. CD7(-) T cells are generated in vitro from naive CD7(+) T cells upon repetitive TCR/CD28 engagement, a process that is unidirectional and requires multiple cell divisions. Consequently, clonal expansions of CD7(-) T cells in vivo are less frequent than of CD7(+) T cells, the former can be traced back to those of CD7(+) T cells.
语言:: eng
DOI:: 10.1089/rej.2007.0612

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