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PMID: 18566695 Published · epublish English Journal Article Review

The role of erythropoietin as an inhibitor of tissue ischemia.

International journal of biological sciences ·Vol. 4 ·No. 3 ·2008-06-10 ·Pages 161-8

Paschos N, Lykissas MG, Beris AE

Abstract

Erythropoietin is a hypoxia-induced cytokine that stimulates erythropoiesis through the promotion of erythroid precursor cell proliferation and differentiation. Recent evidence supports that erythropoietin has a broad spectrum of tissue protecting actions affecting other systems than hemopoietic. Lately, research has focused on the nonhemopoietic effects of erythropoietin against tissue ischemia due to the unexpected observations of erythropoietin receptor expression by various cells, such as endothelial cells, neuronal cells, cardiac myocytes, and vascular smooth muscle cells. It has been shown that erythropoietin exerts its cardioprotective action during cardiac ischemic injury through reducing the infract size and enhancing new vessel formation over a longer time frame. Erythropoietin plays a crucial role in neuroprotection in many types of ischemic injury in the central and the peripheral nervous system. It is also strongly believed that erythropoietin exhibits a critical role in many other disorders that are pathogenetically related to acute tissue ischemia. This article reviews the proposed implications of erythropoietin in tissue ischemia and discusses the possible mechanisms for this action along with its potential therapeutic applications.

Keywords
cardiovascular system erythropoietin ischemia ischemia/reperfusion injury nervous system
MeSH Terms
Animals Apoptosis Cardiovascular System/metabolism Cell Survival Endothelial Cells/metabolism Erythropoietin/physiology Humans Hypoxia Ischemia/drug therapy Models, Biological Nervous System/metabolism Neurons/metabolism Oxygen/metabolism Reperfusion Injury/drug therapy
Chemicals
Erythropoietin Oxygen
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Paschos Nikolaos
Department of Orthopaedic Surgery, University of Ioannina School of Medicine, Ioannina, P.O. Box 45110, Greece.
Lykissas Marios G
Beris Alexandros E
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Article Info
Journal
International journal of biological sciences
Abbr.
Int J Biol Sci
ISSN
1449-2288
DOI
10.7150/ijbs.4.161
Published
2008-06-10
Epub
2008-00-10
Pages
161-8
Language
English
Region
Australia
NLM ID
101235568
PMCID
PMC2430987
Subset
IM
External Links
PubMed source DOI: 10.7150/ijbs.4.161 PMC Full Text View journal details
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