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PMID: 18558577 Published · ppublish English Journal Article Review

Gynecologic cancers associated with Lynch syndrome/HNPCC.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico ·Vol. 10 ·No. 6 ·2008-06-00 ·Pages 313-7

Schmeler KM, Lu KH

Abstract

Lynch syndrome/hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant inherited cancer susceptibility syndrome caused by a germline mutation in one of the deoxyribonucleic acid (DNA) mismatch repair genes. It is associated with early onset of cancer (age younger than 50 years) and the development of multiple cancer types, particularly colon and endometrial cancer. Women with Lynch syndrome have a 40-60% risk of endometrial cancer, which equals or exceeds their risk of colorectal cancer. In addition, they have a 12% risk of ovarian cancer. Despite limited information on the efficacy of surveillance in reducing endometrial and ovarian cancer risk in women with Lynch syndrome, the current gynecologic cancer screening guidelines include annual endometrial sampling and transvaginal ultrasonography beginning at age 30-35 years. In addition, risk-reducing surgery consisting of prophylactic hysterectomy and bilateral salpingooophorectomy should be offered to women aged 35 years or older who do not wish to preserve their fertility.

MeSH Terms
Adult Colorectal Neoplasms, Hereditary Nonpolyposis/complications Female Genetic Predisposition to Disease Genital Neoplasms, Female/complications Humans Middle Aged
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schmeler K M
Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, USA. kschmele@mdanderson.org
Lu K H
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Article Info
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Abbr.
Clin Transl Oncol
ISSN
1699-048X
DOI
10.1007/s12094-008-0206-9
Email
kschmele@mdanderson.org
Published
2008-06-00
Pages
313-7
Language
English
Region
Italy
NLM ID
101247119
Subset
IM
External Links
PubMed source DOI: 10.1007/s12094-008-0206-9 View journal details
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