Rewiring bacteria, two components at a time.

Cell ·Vol. 133 ·No. 6 ·2008-06-13 ·Pages 947-8

Kohanski MA, Collins JJ

Abstract

In this issue, Skerker et al. (2008) present a rational method for rewiring the protein-protein interactions and output responses of prokaryotic two-component signal transduction systems. This work has important implications for understanding the specificity of protein interactions and for designing protein-based synthetic signaling cascades.

MeSH Terms

Bacteria/enzymology,genetics,metabolism Bacterial Proteins/chemistry,genetics,metabolism Protein Engineering Signal Transduction

Chemicals

Bacterial Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kohanski Michael A

Department of Biomedical Engineering, Center for BioDynamics, and Center for Advanced Biotechnology, Boston University, 44 Cummington St., Boston, MA 02215, USA.

Collins James J

Article Info

Journal

Cell

Abbr.

Cell

ISSN

1097-4172

DOI

10.1016/j.cell.2008.05.035

Published

2008-06-13

Pages

947-8

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 18555780

External Links

PubMed source DOI: 10.1016/j.cell.2008.05.035 View journal details

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Rewiring bacteria, two components at a time.

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