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题目:: Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma A431.
作者:: Atsumi(Naho),Ishii(Genichiro),Kojima(Motohiro),Sanada(Masaru),Fujii(Satoshi),Ochiai(Atsushi)
状态:: 发布时间2008-07-01 , 更新时间 2015-11-19
期刊:: Biochem Biophys Res Commun
摘要:: Squamous cell carcinoma (SCC) is a malignant tumor that shows morphologic and phenotypic similarities to normally differentiated squamous epithelium. Thus, it may be an ideal model for seeking a marker of tumor-initiating cells (TICs) based on their morphology. Using the human SCC cell line A431, we found that, as a paradigm of cancer stem cells: (1) podoplanin(+) cells generate both podoplanin(+) and podoplanin(-) cells; (2) podoplanin(-) cells rarely generate podoplanin(+) cells; (3) podoplanin(+) cells have higher colony formation efficiency and tumorigenicity than podoplanin(-) cells; (4) localization and morphology of podoplanin(+) cells in a xenografted tumor derived from podoplanin(+) cells are similar with those in human oral SCC tissue or normal epithelium. Furthermore, podoplanin(+) A431 cells share sonic hedgehog and CD44 expression with stem cells in normal squamous epithelium. Hence, we concluded that podoplanin is a novel marker to enrich TICs with stem-cell-like properties from SCC cell line A431.
语言:: eng
DOI:: 10.1016/j.bbrc.2008.05.163

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