Abstract
Mutations in mitochondrial small subunit ribosomal proteins MRPS16 or MRPS22 cause severe, fatal respiratory chain dysfunction due to impaired translation of mitochondrial mRNAs. The loss of either MRPS16 or MRPS22 was accompanied by the loss of most of another small subunit protein MRPS11. However, MRPS2 was reduced only about 2-fold in patient fibroblasts. This observation suggests that the small ribosomal subunit is only partially able to assemble in these patients. Two large subunit ribosomal proteins, MRPL13 and MRPL15, were present in substantial amounts suggesting that the large ribosomal subunit is still present despite a non-functional small subunit.
MeSH Terms
DNA, Mitochondrial/genetics,metabolism
Humans
Mitochondria/genetics,physiology
Mitochondrial Proteins/genetics,physiology
Models, Molecular
Mutation
RNA, Ribosomal/genetics
RNA, Ribosomal, 16S/genetics
Ribosomal Proteins/genetics,physiology
Ribosome Subunits, Large/metabolism
Ribosome Subunits, Small/metabolism
Chemicals
DNA, Mitochondrial
MRPS22 protein, human
Mitochondrial Proteins
RNA, Ribosomal
RNA, Ribosomal, 16S
Ribosomal Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Emdadul Haque Md
Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3290, USA.
Grasso Domenick
Miller Chaya
Spremulli Linda L
Saada Ann
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