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PMID: 18532987 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Secretory outposts for the local processing of membrane cargo in neuronal dendrites.

Traffic (Copenhagen, Denmark) ·Vol. 9 ·No. 9 ·2008-09-00 ·Pages 1437-45

Hanus C, Ehlers MD

Abstract

The large size and geometric complexity of neuronal dendrites necessitate specialized mechanisms to both deliver postsynaptic cargo over extended distances and regulate dendritic composition on a submicron scale. Despite the fundamental importance of membrane trafficking in dendrite growth, synapse formation and plasticity, the organelles and cellular rules governing postsynaptic trafficking are only now emerging. Here we review what is currently known about dendritic secretory organelles and their role in the development, maintenance and plasticity of postsynaptic compartments.

MeSH Terms
Animals Cell Membrane/metabolism,physiology,ultrastructure Dendrites/metabolism,physiology,ultrastructure Humans Membrane Proteins/metabolism Neuronal Plasticity/physiology Organelles/metabolism,physiology,ultrastructure Protein Folding Protein Transport Secretory Pathway/physiology Synaptic Transmission/physiology
Chemicals
Membrane Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hanus Cyril
Department of Neurobiology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.
Ehlers Michael D
References (68)
68 references, click to expand
  1. Dendritic and postsynaptic protein synthetic machinery.
    J Neurosci. 1999 Jan 1;19(1):168-79 PMID: 9870948
  2. Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta.
    Cell. 2001 Aug 24;106(4):489-98 PMID: 11525734
  3. The organization of the endoplasmic reticulum and the intermediate compartment in cultured rat hippocampal neurons.
    Mol Biol Cell. 1995 Oct;6(10):1315-32 PMID: 8573789
  4. Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin.
    J Neurosci. 2007 Jan 31;27(5):1033-44 PMID: 17267557
  5. Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases.
    Nat Neurosci. 2004 Feb;7(2):136-44 PMID: 14703572
  6. mRNA localization and ER-based protein sorting mechanisms dictate the use of transitional endoplasmic reticulum-golgi units involved in gurken transport in Drosophila oocytes.
    Mol Biol Cell. 2004 Dec;15(12):5306-17 PMID: 15385627
  7. Growing dendrites and axons differ in their reliance on the secretory pathway.
    Cell. 2007 Aug 24;130(4):717-29 PMID: 17719548
  8. Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation.
    Cell. 1983 Aug;34(1):233-43 PMID: 6883510
  9. Polarity orientation of microtubules in hippocampal neurons: uniformity in the axon and nonuniformity in the dendrite.
    Proc Natl Acad Sci U S A. 1988 Nov;85(21):8335-9 PMID: 3054884
  10. Protein synthesis within dendrites: glycosylation of newly synthesized proteins in dendrites of hippocampal neurons in culture.
    J Neurosci. 1996 Oct 1;16(19):5967-78 PMID: 8815879
  11. Endosomal compartments serve multiple hippocampal dendritic spines from a widespread rather than a local store of recycling membrane.
    J Neurosci. 2002 Mar 15;22(6):2215-24 PMID: 11896161
  12. Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus.
    Neuron. 1998 Sep;21(3):545-59 PMID: 9768841
  13. Evidence for a satellite secretory pathway in neuronal dendritic spines.
    Curr Biol. 2001 Mar 6;11(5):351-5 PMID: 11267872
  14. Asymmetrical allocation of NMDA receptor epsilon2 subunits in hippocampal circuitry.
    Science. 2003 May 9;300(5621):990-4 PMID: 12738868
  15. Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat.
    J Neurosci. 1997 Jan 1;17(1):190-203 PMID: 8987748
  16. RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum.
    Neuron. 2002 May 30;34(5):759-72 PMID: 12062022
  17. Centrosome localization determines neuronal polarity.
    Nature. 2005 Aug 4;436(7051):704-8 PMID: 16079847
  18. Endoplasmic reticulum architecture: structures in flux.
    Curr Opin Cell Biol. 2006 Aug;18(4):358-64 PMID: 16806883
  19. Fragmentation of the Golgi apparatus in neurodegenerative diseases and cell death.
    J Neurol Sci. 2006 Jul 15;246(1-2):21-30 PMID: 16545397
  20. Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons.
    J Neurosci. 2006 Aug 9;26(32):8339-51 PMID: 16899729
  21. The centrosome in neuronal development.
    Trends Neurosci. 2007 Jun;30(6):276-83 PMID: 17420058
  22. Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network.
    Dev Cell. 2007 Jun;12(6):917-30 PMID: 17543864
  23. The formation of TGN-to-plasma-membrane transport carriers.
    Annu Rev Cell Dev Biol. 2006;22:439-55 PMID: 16824007
  24. Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors.
    Neuron. 2003 Oct 30;40(3):581-94 PMID: 14642281
  25. The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus.
    Curr Opin Cell Biol. 2004 Aug;16(4):356-63 PMID: 15261667
  26. The Golgi apparatus: 100 years of progress and controversy.
    Trends Cell Biol. 1998 Jan;8(1):2-10 PMID: 9695800
  27. Dendritic spines: structure, dynamics and regulation.
    Nat Rev Neurosci. 2001 Dec;2(12):880-8 PMID: 11733795
  28. Dual modes of endoplasmic reticulum-to-Golgi transport in dendrites revealed by live-cell imaging.
    J Neurosci. 2003 Jul 16;23(15):6188-99 PMID: 12867502
  29. Involvement of the secretory pathway for AMPA receptors in NMDA-induced potentiation in hippocampus.
    J Neurosci. 2001 Jan 1;21(1):27-34 PMID: 11150316
  30. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide.
    Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12 PMID: 17245412
  31. Calcium-evoked dendritic exocytosis in cultured hippocampal neurons. Part I: trans-Golgi network-derived organelles undergo regulated exocytosis.
    J Neurosci. 1998 Sep 1;18(17):6803-13 PMID: 9712651
  32. Endoplasmic reticulum export site formation and function in dendrites.
    J Neurosci. 2004 Apr 14;24(15):3770-6 PMID: 15084657
  33. Neural cell adhesion molecule promotes accumulation of TGN organelles at sites of neuron-to-neuron contacts.
    J Cell Biol. 2002 Nov 25;159(4):649-61 PMID: 12438412
  34. Polarity and intracellular compartmentalization of Drosophila neurons.
    Neural Dev. 2007 Apr 30;2:7 PMID: 17470283
  35. Polarized distribution of the trans-Golgi network marker TGN38 during the in vitro development of neocortical neurons: effects of nocodazole and brefeldin A.
    Eur J Neurosci. 1994 Sep 1;6(9):1453-65 PMID: 8000569
  36. Stores not just for storage. intracellular calcium release and synaptic plasticity.
    Neuron. 2001 Aug 30;31(4):519-22 PMID: 11545711
  37. Organelles and trafficking machinery for postsynaptic plasticity.
    Annu Rev Neurosci. 2006;29:325-62 PMID: 16776589
  38. Cell type-specific dendritic polarity in the absence of spatially organized external cues.
    Brain Cell Biol. 2006 Feb;35(1):29-38 PMID: 17940911
  39. Calcium-evoked dendritic exocytosis in cultured hippocampal neurons. Part II: mediation by calcium/calmodulin-dependent protein kinase II.
    J Neurosci. 1998 Sep 1;18(17):6814-21 PMID: 9712652
  40. On the structure of nerve cells. 1898.
    J Microsc. 1989 Jul;155(Pt 1):3-7 PMID: 2671382
  41. Heterogeneous distribution of the cAMP receptor protein RII in the nervous system: evidence for its intracellular accumulation on microtubules, microtubule-organizing centers, and in the area of the Golgi complex.
    J Cell Biol. 1986 Jul;103(1):189-203 PMID: 3522603
  42. Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes.
    Neuron. 2006 Dec 7;52(5):817-30 PMID: 17145503
  43. Dendritic protein synthesis, synaptic plasticity, and memory.
    Cell. 2006 Oct 6;127(1):49-58 PMID: 17018276
  44. Local calcium release in dendritic spines required for long-term synaptic depression.
    Neuron. 2000 Oct;28(1):233-44 PMID: 11086997
  45. Diffusion in inhomogeneous media: theory and simulations applied to whole cell photobleach recovery.
    Biophys J. 2000 Oct;79(4):1761-70 PMID: 11023884
  46. Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity.
    Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10494-9 PMID: 12928494
  47. PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants.
    Neuron. 2000 Dec;28(3):887-98 PMID: 11163274
  48. Using temperature-sensitive mutants of VSV to study membrane protein biogenesis.
    Methods Cell Biol. 1989;32:85-110 PMID: 2558277
  49. Bi-directional protein transport between the ER and Golgi.
    Annu Rev Cell Dev Biol. 2004;20:87-123 PMID: 15473836
  50. The control of dendrite development.
    Neuron. 2003 Oct 9;40(2):229-42 PMID: 14556706
  51. Stimulation of glutamate receptor protein synthesis and membrane insertion within isolated neuronal dendrites.
    Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11545-50 PMID: 11027353
  52. Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning.
    Neuron. 2006 Aug 3;51(3):283-90 PMID: 16880123
  53. Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2.
    Neuron. 2006 Jun 15;50(6):897-909 PMID: 16772171
  54. Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis.
    Neuron. 2005 Dec 8;48(5):757-71 PMID: 16337914
  55. Local caspase activity directs engulfment of dendrites during pruning.
    Nat Neurosci. 2006 Oct;9(10):1234-6 PMID: 16980964
  56. AMPA receptor biogenesis and trafficking.
    Curr Opin Neurobiol. 2007 Jun;17(3):289-97 PMID: 17475474
  57. Molecular basis for Golgi maintenance and biogenesis.
    Curr Opin Cell Biol. 2004 Aug;16(4):364-72 PMID: 15261668
  58. Secretory trafficking in neuronal dendrites.
    Nat Cell Biol. 2004 Jul;6(7):585-91 PMID: 15232591
  59. Recycling endosomes supply AMPA receptors for LTP.
    Science. 2004 Sep 24;305(5692):1972-5 PMID: 15448273
  60. Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors.
    Nat Neurosci. 2004 Mar;7(3):244-53 PMID: 14770185
  61. Citron-N is a neuronal Rho-associated protein involved in Golgi organization through actin cytoskeleton regulation.
    Nat Cell Biol. 2003 Dec;5(12):1071-8 PMID: 14595335
  62. Targeted trafficking of neurotransmitter receptors to synaptic sites.
    Mol Neurobiol. 2002 Aug;26(1):117-35 PMID: 12392061
  63. ERK1c regulates Golgi fragmentation during mitosis.
    J Cell Biol. 2006 Mar 13;172(6):885-97 PMID: 16533948
  64. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking.
    Trends Cell Biol. 2006 Oct;16(10):522-9 PMID: 16949823
  65. NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area.
    J Neurosci. 2000 Apr 1;20(7):2512-22 PMID: 10729331
  66. Compartmentalized synthesis and degradation of proteins in neurons.
    Neuron. 2003 Oct 9;40(2):347-59 PMID: 14556713
  67. Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines.
    Nat Neurosci. 2000 Apr;3(4):311-3 PMID: 10725917
  68. An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing.
    J Neurosci. 2001 May 1;21(9):3063-72 PMID: 11312291
Article Info
Journal
Traffic (Copenhagen, Denmark)
Abbr.
Traffic
ISSN
1600-0854
DOI
10.1111/j.1600-0854.2008.00775.x
Published
2008-09-00
Epub
2008-00-04
Pages
1437-45
Language
English
Region
England
NLM ID
100939340
PMCID
PMC2572994
Subset
IM
Grants
NINDS NIH HHS · R01 NS039402-08 · United States
Howard Hughes Medical Institute · United States
NINDS NIH HHS · R01 NS039402-09 · United States
NINDS NIH HHS · R01 NS039402-07 · United States
NINDS NIH HHS · R01 NS039402-10 · United States
NINDS NIH HHS · R01 NS039402 · United States
NINDS NIH HHS · R01 NS039402-06 · United States
External Links
PubMed source DOI: 10.1111/j.1600-0854.2008.00775.x PMC Full Text View journal details
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