| GeneLibs

题目:: Laforin confers cancer resistance to energy deprivation-induced apoptosis.
作者:: Wang(Yin),Liu(Yan),Wu(Cindy),McNally(Beth),Liu(Yang),Zheng(Pan)
状态:: 发布时间2008-06-03 , 更新时间 2016-11-22
期刊:: Cancer Res
摘要:: A long-standing but poorly understood observation in experimental cancer therapy is the heterogeneity in cancer susceptibility to energy deprivation. Here, we show that the hexose kinase inhibitor 2-deoxyglucose (2-dG) preferentially kills cancer cells with defective laforin expression and significantly increases the survival of mice with aggressive lymphoma due to a genetic defect of the laforin-encoding Epm2a gene. Normal cells from Epm2a(-/-) mice also had greatly increased susceptibility to 2-dG. Thus, laforin is a novel regulator for cellular response to energy deprivation and its defects in cancer cells may be targeted for cancer therapy.
语言:: eng
DOI:

文献库文献相关信息