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PMID: 18514521 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Growth control by intracellular tension and extracellular stiffness.

Trends in cell biology ·Vol. 18 ·No. 7 ·2008-07-00 ·Pages 347-52

Assoian RK, Klein EA

Abstract

Integrin-mediated cell attachment to the extracellular matrix is an established regulator of the cell cycle, and the best-characterized targets of this process are the cyclin D1 gene and members of the cip and kip (cip/kip) family of cdk inhibitors. Manipulation of intracellular tension affects the same targets, supporting the idea that integrin activation and intracellular tension are closely related. Several signaling cascades, including FAK, Rho GTPases and ERK, transmit the integrin and tensional signals to pathways controlling the cell cycle. However, the experimental approaches that have generated these results alter cell adhesion and tension in ways that do not reflect the subtlety of those occurring in vivo. Increasing emphasis is therefore being placed on approaches that use micropatterning to control cell spreading, and deformable substrata to model the compliance of biological tissue.

MeSH Terms
Actins/metabolism Animals Cell Adhesion Cell Cycle Cell Movement Cell Proliferation Cyclin D1/metabolism Enzyme Inhibitors/pharmacology Extracellular Matrix/metabolism Extracellular Signal-Regulated MAP Kinases/metabolism Humans Integrins/metabolism Models, Biological Signal Transduction rho GTP-Binding Proteins/metabolism
Chemicals
Actins Enzyme Inhibitors Integrins Cyclin D1 Extracellular Signal-Regulated MAP Kinases rho GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Assoian Richard K
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA. assoian@mail.med.upenn.edu
Klein Eric A
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2008.05.002
Email
assoian@mail.med.upenn.edu
Published
2008-07-00
Epub
2008-00-29
Pages
347-52
Language
English
Region
England
NLM ID
9200566
PMCID
PMC2888483
Subset
IM
Grants
NHLBI NIH HHS · R01 HL094491 · United States
NHLBI NIH HHS · R01 HL083367 · United States
NCI NIH HHS · R01 CA072639-11 · United States
NHLBI NIH HHS · R01 HL094491-01A1 · United States
NHLBI NIH HHS · P01 HL062250 · United States
NHLBI NIH HHS · P01 HL062250-100004 · United States
NCI NIH HHS · R01 CA072639 · United States
NHLBI NIH HHS · R01 HL083367-03 · United States
External Links
PubMed source DOI: 10.1016/j.tcb.2008.05.002 PMC Full Text View journal details
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