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PMID: 1849640 Published · ppublish English Journal Article Review

Development of delta opioid peptides as nonaddicting analgesics.

Pharmaceutical research ·Vol. 8 ·No. 1 ·1991-01-00 ·Pages 1-8

Rapaka RS, Porreca F

Abstract

Although much effort has been devoted to opioid research since the identification of enkephalins, understanding of the physiological importance and mechanisms of action of endogenous opioids lags behind understanding of opiate alkaloids such as morphine. In recent years, several novel approaches have been refined with promise for the successful development of the long-awaited nonaddicting analgesics that act at the opioid delta receptor. The present communication reviews these efforts.

MeSH Terms
Analgesics/pharmacology Drug Design Humans Male Narcotics/chemical synthesis,pharmacology Receptors, Opioid/drug effects Receptors, Opioid, delta
Chemicals
Analgesics Narcotics Receptors, Opioid Receptors, Opioid, delta
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rapaka R S
Division of Preclinical Research, National Institute on Drug Abuse, Rockville, Maryland 20857.
Porreca F
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Article Info
Journal
Pharmaceutical research
Abbr.
Pharm Res
ISSN
0724-8741
DOI
10.1023/a:1015809702296
Published
1991-01-00
Pages
1-8
Language
English
Region
United States
NLM ID
8406521
Subset
IM
External Links
PubMed source DOI: 10.1023/a:1015809702296 View journal details
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