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PMID: 18493648 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues.

Molecular bioSystems ·Vol. 4 ·No. 6 ·2008-06-00 ·Pages 518-20

Kiburu I, Shurer A, Yan L, Sintim HO

Abstract

Cyclic-di-guanylate (c-di-GMP) has emerged as a general and important signaling molecule uniquely present in bacteria: herein we provide a simple solid-phase synthesis of c-di-GMP using an automated DNA synthesizer for the majority of the synthesis.

MeSH Terms

Bacteria/chemistry Chromatography, High Pressure Liquid Cyclic GMP/analogs & derivatives,chemical synthesis,chemistry Cyclization Molecular Conformation Signal Transduction Stereoisomerism

Chemicals

bis(3',5')-cyclic diguanylic acid Cyclic GMP

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kiburu Irene

Department of Chemistry and Biochemistry, Building 091, University of Maryland, College Park, MD 20742, USA. hsintim@umd.edu.

Shurer Andrew

Yan Lei

Sintim Herman O

Article Info

Journal

Molecular bioSystems

Abbr.

Mol Biosyst

ISSN

1742-2051

DOI

10.1039/b719423d

hsintim@umd.edu

Published

2008-06-00

Epub

2008-00-29

Pages

518-20

Language

English

Region

England

NLM ID

101251620

Subset

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1039/b719423d

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A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues.

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