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PMID: 1849233 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Primary structure and functional expression from complementary DNA of a brain calcium channel.

Nature ·Vol. 350 ·No. 6317 ·1991-04-04 ·Pages 398-402

Mori Y, Friedrich T, Kim MS, Mikami A, Nakai J, Ruth P, Bosse E, Hofmann F, Flockerzi V, Furuichi T

Abstract

The primary structure of a voltage-dependent calcium channel from rabbit brain has been deduced by cloning and sequencing the complementary DNA. Calcium channel activity expressed from the cDNA is dramatically increased by coexpression of the alpha 2 and beta subunits, known to be associated with the dihydropyridine receptor. This channel is a high voltage-activated calcium channel that is insensitive both to nifedipine and to omega-conotoxin. We suggest that it is expressed predominantly in cerebellar Purkinje cells and granule cells.

MeSH Terms

Amino Acid Sequence Animals Blotting, Northern Brain Calcium Channels/genetics,physiology Cloning, Molecular DNA/genetics Gene Expression Microinjections Molecular Sequence Data RNA, Messenger/administration & dosage,genetics Rabbits Tissue Distribution Xenopus

Chemicals

Calcium Channels RNA, Messenger DNA

Authors & Affiliations

10 authors, click to expand affiliations / ORCID

Mori Y

Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.

Friedrich T

Kim M S

Mikami A

Nakai J

Ruth P

Bosse E

Hofmann F

Flockerzi V

Furuichi T

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/350398a0

Published

1991-04-04

Pages

398-402

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

X57450, X57451, X57452, X57453, X57454, X57455, X57476, X57477, X57688, X57689

External Links

PubMed source DOI: 10.1038/350398a0 View journal details

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Primary structure and functional expression from complementary DNA of a brain calcium channel.

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