Stopping replication, at the beginning.

Animals Antineoplastic Agents/chemistry,pharmacology Cell Cycle/drug effects Cell Cycle Proteins/antagonists & inhibitors,drug effects,genetics,metabolism Cell Line, Tumor Cell Proliferation/drug effects DNA/biosynthesis,drug effects DNA Replication/drug effects Humans Minichromosome Maintenance Complex Component 2 Nuclear Proteins/drug effects,metabolism Phosphorylation Piperidones/chemistry,pharmacology Protein Kinase Inhibitors/chemistry,pharmacology Protein Serine-Threonine Kinases/antagonists & inhibitors,genetics,metabolism Pyrroles/chemistry,pharmacology Xenograft Model Antitumor Assays

Antineoplastic Agents Cell Cycle Proteins Nuclear Proteins PHA 767491 Piperidones Protein Kinase Inhibitors Pyrroles DNA CDC7 protein, human Protein Serine-Threonine Kinases MCM2 protein, human Minichromosome Maintenance Complex Component 2