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PMID: 18463092 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction.

The Journal of biological chemistry ·Vol. 283 ·No. 31 ·2008-08-01 ·Pages 21305-9

Schaefer L, Iozzo RV

Abstract

The small leucine-rich proteoglycan (SLRP) family has significantly expanded in the past decade to now encompass five discrete classes, grouped by common structural and functional properties. Some of these gene products are not classical proteoglycans, whereas others have new and unique features. In addition to being structural proteins, SLRPs constitute a network of signal regulation: being mostly extracellular, they are upstream of multiple signaling cascades. They affect intracellular phosphorylation, a major conduit of information for cellular responses, and modulate distinct pathways, including those driven by bone morphogenetic protein/transforming growth factor beta superfamily members, receptor tyrosine kinases such as ErbB family members and the insulin-like growth factor I receptor, and Toll-like receptors. The wealth of mechanistic insights into the molecular and cellular functions of SLRPs has revealed both the sophistication of this family of regulatory proteins and the challenges that remain in uncovering the totality of their functions. This review is focused on novel biological functions of SLRPs with special emphasis on their protein cores, newly described genetic diseases, and signaling events in which SLRPs play key functions.

MeSH Terms
Animals Bone Morphogenetic Proteins/metabolism Humans Inflammation Leucine/chemistry Models, Biological Models, Genetic Multigene Family Phosphatidylinositol 3-Kinases/metabolism Phylogeny Proteoglycans/chemistry Signal Transduction Transforming Growth Factor beta/metabolism
Chemicals
Bone Morphogenetic Proteins Proteoglycans Transforming Growth Factor beta Phosphatidylinositol 3-Kinases Leucine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schaefer Liliana
Pharmazentrum Frankfurt, Frankfurt, Germany.
Iozzo Renato V
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Article Info
Journal
The Journal of biological chemistry
Abbr.
J Biol Chem
ISSN
0021-9258
DOI
10.1074/jbc.R800020200
Published
2008-08-01
Epub
2008-00-06
Pages
21305-9
Language
English
Region
United States
NLM ID
2985121R
PMCID
PMC2490788
Subset
IM
Grants
NCI NIH HHS · R01 CA 120975 · United States
NCI NIH HHS · R01 CA 39481 · United States
NCI NIH HHS · R01 CA 47282 · United States
External Links
PubMed source DOI: 10.1074/jbc.R800020200 PMC Full Text View journal details
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