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PMID: 18454146 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Common genetic variation near MC4R is associated with waist circumference and insulin resistance.

Nature genetics ·Vol. 40 ·No. 6 ·2008-06-00 ·Pages 716-8

Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, Froguel P, Balding D, Scott J, Kooner JS

Abstract

We carried out a genome-wide association study (318,237 SNPs) for insulin resistance and related phenotypes in 2,684 Indian Asians, with further testing in 11,955 individuals of Indian Asian or European ancestry. We found associations of rs12970134 near MC4R with waist circumference (P = 1.7 x 10(-9)) and, independently, with insulin resistance. Homozygotes for the risk allele of rs12970134 have approximately 2 cm increased waist circumference. Common genetic variation near MC4R is associated with risk of adiposity and insulin resistance.

MeSH Terms
Adiposity Adult Aged Alleles Asians Body Mass Index Case-Control Studies Cohort Studies Female Genetic Linkage Genetic Predisposition to Disease Genetic Variation Genome, Human Homozygote Humans Insulin Resistance/genetics Male Middle Aged Polymorphism, Single Nucleotide Receptor, Melanocortin, Type 4/genetics Risk Factors Waist-Hip Ratio Whites
Chemicals
MC4R protein, human Receptor, Melanocortin, Type 4
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Chambers John C
Department of Epidemiology and Public Health, Imperial College London, Norfolk Pl., London W2 1PG, UK.
Elliott Paul
Zabaneh Delilah
Zhang Weihua
Li Yun
Froguel Philippe
Balding David
Scott James
Kooner Jaspal S
Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1546-1718
DOI
10.1038/ng.156
Published
2008-06-00
Epub
2008-00-04
Pages
716-8
Language
English
Region
United States
NLM ID
9216904
Subset
IM
Grants
Medical Research Council · G0600331 · United Kingdom
British Heart Foundation · SP/04/002 · United Kingdom
Medical Research Council · G0601966 · United Kingdom
Medical Research Council · G0700931 · United Kingdom
Wellcome Trust · 066786 · United Kingdom
External Links
PubMed source DOI: 10.1038/ng.156 View journal details
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